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Fig. 4 | BMC Complementary Medicine and Therapies

Fig. 4

From: In vivo and in vitro safety evaluation of fermented Citrus sunki peel extract: acute and 90-day repeated oral toxicity studies with genotoxicity assessment

Fig. 4

Normal levels of micronucleus formation by fermented C. sunki peel extract. Bone marrow cells collected from male ICR mice (n = 5/group) orally treated with 500, 1000 or 2000 mg/kg BW fermented C. sunki peel extract (FCPE) were examined to determine (a) % polychromatic erythrocytes (PCE) and (b) the number of micronuclei-containing polychromatic erythrocytes (MNPCE) per 1000 polychromatic erythrocytes (PCE). FCPE (gray bars) showed comparable levels of % PCE as well as MNPCE counts to the vehicle control (white bars), while mitomycin C (P9, black bars) induced a significant decrease in % PCE with a marked increase of MNPCE. PCE; polychromatic erythrocytes, NCE; normochromatic erythrocytes, MNPCE; polychromatic erythrocytes with micronuclei. *; p < 0.05 and **; p < 0.01 by Kruskal-Wallis one-way ANOVA followed by post-hoc Tukey’s HSD multiple comparison test

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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