Fig. 3From: In vivo and in vitro safety evaluation of fermented Citrus sunki peel extract: acute and 90-day repeated oral toxicity studies with genotoxicity assessmentLack of chromosome aberration by fermented C. sunki peel extract. Chromosomal aberration test was performed using Chinese Hamster Lung cells. Cells were treated with 1250, 2500 and 5000 μg/mL of fermented C. sunki peel extract (FCPE) for the indicated time with or without metabolic activation using the S-9 factor, and examined to identify cells containing aberrant chromosomes. While the positive controls (P7; mitomycin C and P8; cyclophosphamide, black bars) significantly increased the number of cells with chromosome aberration, FCPE (gray bars) did not show a noticeable change compared to the control (white bars) in all tested conditions. *; p < 0.05 when compared to the control by Fisher’s exact testBack to article page