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Table 1 The top 20 biological processes enriched by the 54 putative targets

From: Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach

Term Count of Proteins % p -Value
positive regulation of nitric oxide biosynthetic process 14 25.93 2.12 × 10−23
inflammatory response 20 37.04 1.89 × 10−18
positive regulation of transcription from RNA polymerase II promoter 26 48.15 1.90 × 10−17
positive regulation of smooth muscle cell proliferation 12 22.22 3.09 × 10−17
lipopolysaccharide-mediated signaling pathway 10 18.52 4.01 × 10−16
positive regulation of gene expression 16 29.63 1.99 × 10−15
response to drug 16 29.63 1.76 × 10−14
cellular response to lipopolysaccharide 12 22.22 4.69 × 10−14
response to lipopolysaccharide 13 24.07 9.47 × 10−14
positive regulation of transcription, DNA-templated 18 33.33 1.69 × 10−13
aging 12 22.22 3.15 × 10−12
cellular response to organic cyclic compound 9 16.67 1.11 × 10−11
angiogenesis 12 22.22 8.27 × 10−11
positive regulation of protein phosphorylation 10 18.52 2.04 × 10−10
movement of cell or subcellular component 9 16.67 2.49 × 10−10
response to antibiotic 7 12.96 6.28 × 10−10
negative regulation of apoptotic process 14 25.93 1.12 × 10−9
cellular response to mechanical stimulus 8 14.81 2.36 × 10−9
negative regulation of cell proliferation 13 24.07 2.79 × 10−9
positive regulation of ERK1 and ERK2 cascade 10 18.52 3.53 × 10−9