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Table 6 Major metabolite changes observed in normal: control (C), cisplatin induced (CIS) and aqueous extract pre-treatment (AQ) of NRK-52E cells extract, ***p < 0.0001, **p < 0.001, *p < 0.05

From: NMR and LCMS analytical platforms exhibited the nephroprotective effect of Clinacanthus nutans in cisplatin-induced nephrotoxicity in the in vitro condition

Metabolite δH ppm (multiplicity) CIS vs C AQ vs C
Acetate 1.90 (s) 0.42** 0.51**
Alanine 1.46 (d, 7.2 Hz) 0.70** 1.16***
Choline 3.18 (s) 4.07*** 2.26***
Creatine 3.02 (s) 1.66*** 1.76***
Ethanol 1.17(t) 0.48** 0.61**
Glutamate 2.14 (m), 2.38 (m) 0.20* 0.43**
Glycerophosphocholine (GPC) 3.22 (s) 0.44** 0.35*
Lactate 1.30 (d, 6.7 Hz) 0.42** 0.92**
Lysine 1.54 (m) 1.62*** 0.74**
Phosphocholine 3.20 (s), 3.58 (m), 4.15 (m) 1.33*** 1.61***