Table 2 Major metabolite changes observed in normal: control (C) and cisplatin-induced (CIS) of NRK-52E cells extract, ***p < 0.0001, **p < 0.001, *p < 0.05
No. | Metabolite | δH ppm (multiplicity) | Fold changes | Metabolic pathway |
|---|---|---|---|---|
1 | Acetate | 1.90 (s) | 0.42** | Glycolysis |
2 | Alanine | 1.46 (d, 7.2 Hz) | 0.70** | Amino acid metabolism |
3 | Choline | 3.18 (s) | 4.07*** | Lipid metabolism |
4 | Creatine | 3.02 (s) | 1.66*** | Energy metabolism |
5 | Ethanol | 1.17(t) | 0.48** | Glycolysis |
6 | Glutamate | 2.14 (m), 2.38 (m) | 0.20* | Amino acid metabolism |
7 | Glycerophosphocholine (GPC) | 3.22 (s) | 0.44** | Lipid metabolism |
8 | Lactate | 1.30 (d, 6.7 Hz) | 0.42** | Glycolysis |
9 | Lysine | 1.54 (m) | 1.62*** | Amino acid metabolism |
10 | Phosphocholine | 3.20 (s), 3.58 (m), 4.15 (m) | 1.33*** | Lipid metabolism |