Table 1 Current in vivo studies on the therapeutic mechanism of actions of DSS against AD
Year | Brief description | PMID |
|---|---|---|
2020 | Ameliorating cognition deficits in APP/PS1 mice via increasing DHA content and regulating oxidative stress and inflammation | 32084555 |
2014 | Improving learning and memory in female SAMP8 mice via modulating estrogen, nitric oxide, and glycine in plasma or hippocampal tissue | 24757492 |
2011 | Improving cognition of the rats which might be related to attenuate inflammatory reaction and reduce cell apoptosis in the hippocampus | 22375398 |
2010 | Improving spatial learning and memory deficits in mice, reverse the inhibition of Long-term potentiation in hippocampal slices, prevent aggregation of Aβ, and even disrupt the aggregated Aβ fibrils | 20117199 |
2008 | Upregulating Bcl-2 level and downregulate Bax level which might in turn adjust the mitochondrial membrane permeability, attenuate cytochrome c and its release into cytosol, following the suppression of caspase activation | 18093848 |
2005 | Ameliorating memory dysfunction, modulate metabolism of monoamine neurotransmitters and protect the ultrastructure of cortex changed by aging | 15707771 |
2005 | Reducing the Abeta25–35-induced neuronal death and the lipid peroxidation which has a protective effect against Abeta25–35-induced neuronal damage | 16106382 |