Skip to main content

Table 1 Current in vivo studies on the therapeutic mechanism of actions of DSS against AD

From: Systems pharmacology-based approach to investigate the mechanisms of Danggui-Shaoyao-san prescription for treatment of Alzheimer’s disease

Year Brief description PMID
2020 Ameliorating cognition deficits in APP/PS1 mice via increasing DHA content and regulating oxidative stress and inflammation 32084555
2014 Improving learning and memory in female SAMP8 mice via modulating estrogen, nitric oxide, and glycine in plasma or hippocampal tissue 24757492
2011 Improving cognition of the rats which might be related to attenuate inflammatory reaction and reduce cell apoptosis in the hippocampus 22375398
2010 Improving spatial learning and memory deficits in mice, reverse the inhibition of Long-term potentiation in hippocampal slices, prevent aggregation of Aβ, and even disrupt the aggregated Aβ fibrils 20117199
2008 Upregulating Bcl-2 level and downregulate Bax level which might in turn adjust the mitochondrial membrane permeability, attenuate cytochrome c and its release into cytosol, following the suppression of caspase activation 18093848
2005 Ameliorating memory dysfunction, modulate metabolism of monoamine neurotransmitters and protect the ultrastructure of cortex changed by aging 15707771
2005 Reducing the Abeta25–35-induced neuronal death and the lipid peroxidation which has a protective effect against Abeta25–35-induced neuronal damage 16106382