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Table 8 Effects of sub-chronic oral administration of ICR on the hematological profile of males rats

From: A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings

Males ICR (mg/kg b.w.)
Control 250 500 1000
White blood cells (X 103 /μL) 18.300 ± 0.900 15.830 ± 0.419ns 18.530 ± 1.934ns 19.800 ± 1.400ns
Lymphocytes (%) 82.850 ± 5.250 73.170 ± 11.690ns 65.800 ± 1.900* 63.230 ± 3.150*
Granulocytes (%) 16.000 ± 2.384 23.000 ± 1.277* 23.300 ± 2.000* 24.350 ± 2.850*
Red blood cells (X 106 /μL) 5.150 ± 0.694 5.483 ± 0.131 ns 5.767 ± 0.754 ns 5.187 ± 0.838 ns
Haemoglobin (g/dL) 17.000 ± 1.200 15.930 ± 1.012ns 17.000 ± 0.500ns 14.630 ± 1.635ns
Hematocrit (%) 29.530 ± 1.351 29.100 ± 1.253 ns 29.050 ± 1.650 ns 27.590 ± 1.960 ns
Mean corpuscular volume (fL) 82.530 ± 3.057 78.950 ± 4.122ns 81.650 ± 3.450ns 80.350 ± 4.450ns
Mean corpuscular Hb (pg) 34.170 ± 5.44 33.470 ± 6.130 ns 32.000 ± 5.900 ns 33.100 ± 4.700 ns
MCHC (g/dL) 40.850 ± 2.550 40.600 ± 1.900 ns 50.000 ± 2.300* 52.200 ± 2.010*
RDWCV (%) 18.000 ± 2.200 17.570 ± 2.203ns 19.070 ± 1.602ns 17.000 ± 1.400ns
RDWSD (fL) 44.370 ± 3.168 43.430 ± 3.350ns 65.250 ± 4.750 ns 65.850 ± 4.050ns
Platelets (X 103 /μL) 737.000 ± 60.000 600.0 ± 65.200 ns 650.300 ± 58.800 ns 651.300 ± 60.500 ns
Mean platelet volume (fL) 11.650 ± 0.650 11.530 ± 0.650ns 11.400 ± 0.600ns 10.730 ± 0.611ns
Platelet distribution width (fL) 11.400 ± 0.800 11.000 ± 0.700ns 9.850 ± 1.150ns 10.200 ± 0.400ns
Plateletcrit (%) 0.840 ± 0.180 0.735 ± 0.205ns 0.870 ± 0.040ns 0.935 ± 0.165ns
  1. Results were expressed as Mean ± SEM for n = 5 per group. *:Significantly different from the control at p < 0.05
  2. MCHC Mean corpuscular Haemoglobin concentration, RDWCV Red blood cells distribution width_CV, RDWSD Red blood cells distribution width_SD, ns non significative, ICR methanol extract of the roots of Imperata cylindrica