A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings

Table 8 Effects of sub-chronic oral administration of ICR on the hematological profile of males rats

Males	ICR (mg/kg b.w.)
Males	Control	250	500	1000
White blood cells (X 10³ /μL)	18.300 ± 0.900	15.830 ± 0.419^ns	18.530 ± 1.934^ns	19.800 ± 1.400^ns
Lymphocytes (%)	82.850 ± 5.250	73.170 ± 11.690^ns	65.800 ± 1.900*	63.230 ± 3.150*
Granulocytes (%)	16.000 ± 2.384	23.000 ± 1.277*	23.300 ± 2.000*	24.350 ± 2.850*
Red blood cells (X 10⁶ /μL)	5.150 ± 0.694	5.483 ± 0.131 ^ns	5.767 ± 0.754 ^ns	5.187 ± 0.838 ^ns
Haemoglobin (g/dL)	17.000 ± 1.200	15.930 ± 1.012^ns	17.000 ± 0.500^ns	14.630 ± 1.635^ns
Hematocrit (%)	29.530 ± 1.351	29.100 ± 1.253 ^ns	29.050 ± 1.650 ^ns	27.590 ± 1.960 ^ns
Mean corpuscular volume (fL)	82.530 ± 3.057	78.950 ± 4.122^ns	81.650 ± 3.450^ns	80.350 ± 4.450^ns
Mean corpuscular Hb (pg)	34.170 ± 5.44	33.470 ± 6.130 ^ns	32.000 ± 5.900 ^ns	33.100 ± 4.700 ^ns
MCHC (g/dL)	40.850 ± 2.550	40.600 ± 1.900 ^ns	50.000 ± 2.300^*	52.200 ± 2.010^*
RDWCV (%)	18.000 ± 2.200	17.570 ± 2.203^ns	19.070 ± 1.602^ns	17.000 ± 1.400^ns
RDWSD (fL)	44.370 ± 3.168	43.430 ± 3.350^ns	65.250 ± 4.750 ^ns	65.850 ± 4.050^ns
Platelets (X 10³ /μL)	737.000 ± 60.000	600.0 ± 65.200 ^ns	650.300 ± 58.800 ^ns	651.300 ± 60.500 ^ns
Mean platelet volume (fL)	11.650 ± 0.650	11.530 ± 0.650^ns	11.400 ± 0.600^ns	10.730 ± 0.611^ns
Platelet distribution width (fL)	11.400 ± 0.800	11.000 ± 0.700^ns	9.850 ± 1.150^ns	10.200 ± 0.400^ns
Plateletcrit (%)	0.840 ± 0.180	0.735 ± 0.205^ns	0.870 ± 0.040^ns	0.935 ± 0.165^ns

Results were expressed as Mean ± SEM for n = 5 per group. *:Significantly different from the control at p < 0.05
MCHC Mean corpuscular Haemoglobin concentration, RDWCV Red blood cells distribution width_CV, RDWSD Red blood cells distribution width_SD, ns non significative, ICR methanol extract of the roots of Imperata cylindrica

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