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Table 7 Effects of sub-chronic oral administration of ICR on the hematological profile of females rats

From: A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings

Females ICR (mg/kg b.w.)
Control 250 500 1000
White blood cells (X 103 /μL) 18.650 ± 0.450 15.3000 ± 0.500 ns 17.250 ± 1.150 ns 18.050 ± 1.350ns
Lymphocytes (%) 82.850 ± 1.750 84.700 ± 1.825ns 80.570 ± 0.602 ns 77.500 ± 0.900ns
Granulocytes (%) 14.870 ± 1.365 10.550 ± 1.150* 10.430 ± 1.629* 10.700 ± 0.900*
Red blood cells (X 106 /μL) 7.590 ± 0.130 7.160 ± 0.150ns 7.340 ± 0.100 ns 7.000 ± 0.040ns
Haemoglobin (g/dL) 16.300 ± 0.360 16.130 ± 0.585ns 16.280 ± 1.415ns 15.750 ± 0.550 ns
Hematocrit (%) 44.200 ± 2.000 41.130 ± 2.573ns 41.600 ± 3.677 ns 41.300 ± 1.500 ns
Mean corpuscular volume (fL) 61.350 ± 1.450 59.130 ± 2.196ns 59.050 ± 1.150 ns 59.100 ± 1.800ns
Mean corpuscular Hb (pg) 21.600 ± 0.100 23.130 ± 0.763ns 23.100 ± 0.585 ns 22.300 ± 0.700ns
MCHC (g/dL) 37.200 ± 1.100 38.300 ± 1.200ns 38.800 ± 1.20 ns 38.050 ± 0.050ns
RDWCV (%) 17.570 ± 0.717 17.430 ± 1.050ns 17.900 ± 1.200ns 19.250 ± 1.050ns
RDWSD (fL) 44.330 ± 1.040 43.470 ± 1.350 ns 46.00 ± 1.500 ns 46.100 ± 0.050 ns
Platelets (X 103 /μL) 521.00 ± 8.900 512.0 ± 9.800ns 824.300 ± 6.506* 879.500 ± 7.500*
Mean platelet volume (fL) 11.400 ± 0.900 10.40 ± 1.411ns 11.470 ± 1.305ns 11.900 ± 1.229ns
Platelet distribution width (fL) 11.770 ± 1.002 10.330 ± 1.193ns 10.200 ± 0.900ns 11.770 ± 1.002 ns
Plateletcrit (%) 0.660 ± 0.050 0.585 ± 0.165ns 0.945 ± 0.049ns 0.943 ± 0.136ns
  1. Results were expressed as Mean ± SEM for n = 5 animals per group. *:Significantly different from the control at p < 0.05
  2. MCHC Mean corpuscular Haemoglobin concentration, RDWCV Red blood cells distribution width_CV, RDWSD Red blood cells distribution width_SD, ns non significative, ICR methanol extract of the roots of Imperata cylindrica