A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings

Table 7 Effects of sub-chronic oral administration of ICR on the hematological profile of females rats

Females	ICR (mg/kg b.w.)
Females	Control	250	500	1000
White blood cells (X 10³ /μL)	18.650 ± 0.450	15.3000 ± 0.500 ^ns	17.250 ± 1.150 ^ns	18.050 ± 1.350^ns
Lymphocytes (%)	82.850 ± 1.750	84.700 ± 1.825^ns	80.570 ± 0.602 ^ns	77.500 ± 0.900^ns
Granulocytes (%)	14.870 ± 1.365	10.550 ± 1.150*	10.430 ± 1.629*	10.700 ± 0.900*
Red blood cells (X 10⁶ /μL)	7.590 ± 0.130	7.160 ± 0.150^ns	7.340 ± 0.100 ^ns	7.000 ± 0.040^ns
Haemoglobin (g/dL)	16.300 ± 0.360	16.130 ± 0.585^ns	16.280 ± 1.415^ns	15.750 ± 0.550 ^ns
Hematocrit (%)	44.200 ± 2.000	41.130 ± 2.573^ns	41.600 ± 3.677 ^ns	41.300 ± 1.500 ^ns
Mean corpuscular volume (fL)	61.350 ± 1.450	59.130 ± 2.196^ns	59.050 ± 1.150 ^ns	59.100 ± 1.800^ns
Mean corpuscular Hb (pg)	21.600 ± 0.100	23.130 ± 0.763^ns	23.100 ± 0.585 ^ns	22.300 ± 0.700^ns
MCHC (g/dL)	37.200 ± 1.100	38.300 ± 1.200^ns	38.800 ± 1.20 ^ns	38.050 ± 0.050^ns
RDWCV (%)	17.570 ± 0.717	17.430 ± 1.050^ns	17.900 ± 1.200^ns	19.250 ± 1.050^ns
RDWSD (fL)	44.330 ± 1.040	43.470 ± 1.350 ^ns	46.00 ± 1.500 ^ns	46.100 ± 0.050 ^ns
Platelets (X 10³ /μL)	521.00 ± 8.900	512.0 ± 9.800^ns	824.300 ± 6.506*	879.500 ± 7.500*
Mean platelet volume (fL)	11.400 ± 0.900	10.40 ± 1.411^ns	11.470 ± 1.305^ns	11.900 ± 1.229^ns
Platelet distribution width (fL)	11.770 ± 1.002	10.330 ± 1.193^ns	10.200 ± 0.900^ns	11.770 ± 1.002 ^ns
Plateletcrit (%)	0.660 ± 0.050	0.585 ± 0.165^ns	0.945 ± 0.049^ns	0.943 ± 0.136^ns

Results were expressed as Mean ± SEM for n = 5 animals per group. *:Significantly different from the control at p < 0.05
MCHC Mean corpuscular Haemoglobin concentration, RDWCV Red blood cells distribution width_CV, RDWSD Red blood cells distribution width_SD, ns non significative, ICR methanol extract of the roots of Imperata cylindrica

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