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Table 4 Effects of sub-chronic oral administration of ICR on serum and urinary biochemical parameters in males rats

From: A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings

Females ICR (mg/kg b.w.)
Control 250 500 1000
Serum creatinine (μmol/l) 50.510 ± 1.500 46.300 ± 1.607 ns 53.910 ± 1.730 ns 51.560 ± 1.814 ns
Urinary creatinine (μmol/l) 1088 ± 48.620 1079 ± 40.040ns 670.100 ± 30.000* 1091 ± 50.730ns
Serum urea (mmol/L) 5.650 ± 0.147 5.524 ± 0.175ns 5.697 ± 0.065ns 6.097 ± 0.336ns
Urinary urea (mmol/L) 25.180 ± 0.254 22.690 ± 0.221 ns 24.490 ± 0.689 ns 15.180 ± 0.261 ns
Serum total protein (g/L) 45.300 ± 0.036 48.300 ± 0.044ns 44.900 ± 0.016ns 38.100 ± 0.026ns
Urinary total protein (g/L) 5.856 ± 0.059 6.271 ± 0.524 ns 5.723 ± 0.193 ns 5.395 ± 0.357 ns
ALT (U/L) 34.630 ± 2.014 33.120 ± 2.365 ns 32.00 ± 2.000 ns 31.730 ± 2.026 ns
AST (U/L) 68.770 ± 2.918 54.490 ± 2.258* 42.940 ± 2.029* 50.080 ± 1.747 *
  1. Results were expressed as Mean ± SEM for n = 5 animals per group. *:Significantly different from the control at p < 0.05
  2. ALT Alanine aminotransferase, AST Aspartate aminotransferase, ns non significative, ICR methanol extract of the roots of Imperata cylindrica