Table 4 Effects of sub-chronic oral administration of ICR on serum and urinary biochemical parameters in males rats

Serum creatinine (μmol/l)

50.510 ± 1.500

46.300 ± 1.607 ^ns

53.910 ± 1.730 ^ns

51.560 ± 1.814 ^ns

Urinary creatinine (μmol/l)

1088 ± 48.620

1079 ± 40.040^ns

670.100 ± 30.000*

1091 ± 50.730^ns

Serum urea (mmol/L)

5.650 ± 0.147

5.524 ± 0.175^ns

5.697 ± 0.065^ns

6.097 ± 0.336^ns

Urinary urea (mmol/L)

25.180 ± 0.254

22.690 ± 0.221 ^ns

24.490 ± 0.689 ^ns

15.180 ± 0.261 ^ns

Serum total protein (g/L)

45.300 ± 0.036

48.300 ± 0.044^ns

44.900 ± 0.016^ns

38.100 ± 0.026^ns

Urinary total protein (g/L)

5.856 ± 0.059

6.271 ± 0.524 ^ns

5.723 ± 0.193 ^ns

5.395 ± 0.357 ^ns

ALT (U/L)

34.630 ± 2.014

33.120 ± 2.365 ^ns

32.00 ± 2.000 ^ns

31.730 ± 2.026 ^ns

AST (U/L)

68.770 ± 2.918

54.490 ± 2.258*

42.940 ± 2.029*

50.080 ± 1.747 *