Table 2 The combination index (CI)* values for the Beta vulgaris juice (BVJ) and meso-2,3-dimercaptosuccinic acid (DMSA) mixture on the tested parameters
Parameters | CI | Effect |
|---|---|---|
In vitro antioxidant models | ||
 ABTS (mg/mL) | 0.000 ± 0.000 | Synergistic |
 β-carotene bleaching (mg/mL) | 3.764 ± 0.122 | Antagonistic |
 Ferric reducing power (mg/mL) | 0.245 ± 0.026 | Synergistic |
Liver function parameters | ||
 ALT (U/L) | 0.866 ± 0.072 | Synergistic |
 AST (U/L) | 0.545 ± 0.148 | Synergistic |
 ALP (U/L) | 0.626 ± 0.129 | Synergistic |
 Albumin (mg/dl) | 0.893 ± 0.107 | Synergistic |
 Total protein (g/dl) | 1.006 ± 0.062 | Additive |
Kidney function markers | ||
 Urea (mg/dl) | 0.798 ± 0.067 | Synergistic |
 Creatinine (mg/dl) | 0.725 ± 0.077 | Synergistic |
Lead concentration | ||
 Blood lead level (μg/dl) | 0.037 ± 0.012 | Synergistic |
 Hepatic lead Level (μg/g tissue) | 0.062 ± 0.013 | Synergistic |
Oxidative stress markers | ||
 Lipid peroxidation (pmol/g tissue) | 0.641 ± 0.050 | Synergistic |
 GSH (mg/g tissue) | 0.864 ± 0.019 | Synergistic |
 TAC (μg BHT Eq/g tissue) | 0.969 ± 0.136 | Synergistic |
 SOD (IU/mg protein) | 0.624 ± 0.144 | Synergistic |
 GPX (IU/mg protein) | 0.655 ± 0.099 | Synergistic |
 Catalase (IU/mg protein) | 0.7663 ± 0.162 | Synergistic |
 GST (IU/mg protein) | 1.1262 ± 0.226 | Antagonistic |
 GST α1 (expression fold) | 1.814 ± 0.600 | Antagonistic |
Inflammatory parameters | ||
 NO (mmol/g tissue) | 0.677 ± 0.119 | Synergistic |
 IL-6 (pg/g tissue) | 0.402 ± 0.100 | Synergistic |
 DNA fragmentation (%) | 0.844 ± 0.084 | Synergistic |