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Fig. 10 | BMC Complementary Medicine and Therapies

Fig. 10

From: Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K/AKT pathway

Fig. 10

The effects of Celastrol on nephrin protein levels in the DN rat model using the IHC method. The original magnification is × 200 and × 400. NC group, normal control rats; DN group, high-fat and high-glucose diet-fed STZ-induced DN rats. DN + CL group, DN rats were given by gavage low dose (0.5 mg/kg) Celastrol. DN + CH group, DN rats were given by gavage high dose (1.5 mg/kg/d) Celastrol. DN + INH group, DN rats were intraperitoneally injected with LY294002 (1.2 mg/kg/d). Following the once per day administration of Celastrol or LY294002 for 4 weeks for the intervention, rats were sacrificed nephrin protein levels assayed by IHC method of the renal tissues. DN, diabetic nephropathy. We used the one-way analysis of variance (ANOVA), followed by Turkey’s multiple comparison test to analyze the differences

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