|
Parameters
|
Spironolactone
|
YCHT 1 g/kg + Spironolactone
|
YCHT 3 g/kg + Spironolactone
|
|---|
|
Cum (μg)
|
40.4 ± 17.2
|
74.2 ± 39.3
|
80.1 ± 39.5 *
|
|
Cum% (% kg)
|
0.20 ± 0.09
|
0.37 ± 0.20
|
0.40 ± 0.20 *
|
|
Rmax (μg/hr)
|
3.67 ± 2.07
|
6.34 ± 3.00
|
6.02 ± 2.08
|
|
Tmax (hr)
|
15.3 ± 12.0
|
3.33 ± 3.27 *
|
10.0 ± 4.38
|
|
AURC 0–32 (μg)
|
34.9 ± 14.8
|
67.5 ± 36.5
|
78.1 ± 38.8 *
|
|
Ravg (μg/hr)
|
1.26 ± 0.36
|
2.31 ± 1.93
|
2.52 ± 1.82
|
|
Ke (hr− 1)
|
0.09 ± 0.06
|
0.19 ± 0.14
|
0.36 ± 0.30
|
|
t 1/2 (hr)
|
12.6 ± 12.0
|
5.05 ± 2.87
|
3.77 ± 2.96
|
- Data are expressed as the mean ± S.D. (n = 6)
- Data were significantly different by t-test. * p value < 0.05
- Cum Cumulative amount of canrenone excreted within 32 h., Cum% Percent of cumulative amount excreted versus administration dose, Ravg Average rate of excretion, Rmax Maximum rate of excretion, Tmax Time of maximum rate of excretion, AURC 0–32 Area under the rate of excretion versus midpoint of time interval curve for time 0 to 32 h, Kel Elimination rate constant, t1/2 Elimination half-life, YCHT Chinese herbal formula Yin-Chen-Hao-Tang
