Skip to main content

Table 1 Pharmacokinetic parameters of canrenone in rat urine after single oral administration of spironolactone

From: Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone

Parameters Spironolactone YCHT 1 g/kg + Spironolactone YCHT 3 g/kg + Spironolactone
Cum (μg) 40.4 ± 17.2 74.2 ± 39.3 80.1 ± 39.5 *
Cum% (% kg) 0.20 ± 0.09 0.37 ± 0.20 0.40 ± 0.20 *
Rmax (μg/hr) 3.67 ± 2.07 6.34 ± 3.00 6.02 ± 2.08
Tmax (hr) 15.3 ± 12.0 3.33 ± 3.27 * 10.0 ± 4.38
AURC 0–32 (μg) 34.9 ± 14.8 67.5 ± 36.5 78.1 ± 38.8 *
Ravg (μg/hr) 1.26 ± 0.36 2.31 ± 1.93 2.52 ± 1.82
Ke (hr− 1) 0.09 ± 0.06 0.19 ± 0.14 0.36 ± 0.30
t 1/2 (hr) 12.6 ± 12.0 5.05 ± 2.87 3.77 ± 2.96
  1. Data are expressed as the mean ± S.D. (n = 6)
  2. Data were significantly different by t-test. * p value < 0.05
  3. Cum Cumulative amount of canrenone excreted within 32 h., Cum% Percent of cumulative amount excreted versus administration dose, Ravg Average rate of excretion, Rmax Maximum rate of excretion, Tmax Time of maximum rate of excretion, AURC 0–32 Area under the rate of excretion versus midpoint of time interval curve for time 0 to 32 h, Kel Elimination rate constant, t1/2 Elimination half-life, YCHT Chinese herbal formula Yin-Chen-Hao-Tang