Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone

Table 1 Pharmacokinetic parameters of canrenone in rat urine after single oral administration of spironolactone

Parameters	Spironolactone	YCHT 1 g/kg + Spironolactone	YCHT 3 g/kg + Spironolactone
Cum (μg)	40.4 ± 17.2	74.2 ± 39.3	80.1 ± 39.5 *
Cum% (% kg)	0.20 ± 0.09	0.37 ± 0.20	0.40 ± 0.20 *
R_max (μg/hr)	3.67 ± 2.07	6.34 ± 3.00	6.02 ± 2.08
T_max (hr)	15.3 ± 12.0	3.33 ± 3.27 *	10.0 ± 4.38
AURC _0–32 (μg)	34.9 ± 14.8	67.5 ± 36.5	78.1 ± 38.8 *
R_avg (μg/hr)	1.26 ± 0.36	2.31 ± 1.93	2.52 ± 1.82
K_e (hr^− 1)	0.09 ± 0.06	0.19 ± 0.14	0.36 ± 0.30
t _1/2 (hr)	12.6 ± 12.0	5.05 ± 2.87	3.77 ± 2.96

Data are expressed as the mean ± S.D. (n = 6)
Data were significantly different by t-test. * p value < 0.05
Cum Cumulative amount of canrenone excreted within 32 h., Cum% Percent of cumulative amount excreted versus administration dose, R_avg Average rate of excretion, R_max Maximum rate of excretion, T_max Time of maximum rate of excretion, AURC _0–32 Area under the rate of excretion versus midpoint of time interval curve for time 0 to 32 h, K_el Elimination rate constant, t_1/2 Elimination half-life, YCHT Chinese herbal formula Yin-Chen-Hao-Tang

ISSN: 2662-7671