TY - JOUR AU - Li, Pei-Chuan AU - Chen, Shih-Yi AU - Xiangfei, Danzhou AU - Mao, Canquan AU - Wu, Chieh-His AU - Shih, Jean Chen PY - 2020 DA - 2020/08/15 TI - PAMs inhibits monoamine oxidase a activity and reduces glioma tumor growth, a potential adjuvant treatment for glioma JO - BMC Complementary Medicine and Therapies SP - 252 VL - 20 IS - 1 AB - Monoamine oxidase (MAO) A catalyzes oxidative deamination of monoamine neurotransmitters and dietary amines and regulates brain development and functions. Recently, we showed that MAO A mediates the progression and migration of glioma and MAO A inhibitors reduce glioma cell growth. Glioblastoma (GBM) is a common and most malignant brain tumor which is difficult to treat. Temozolomide (TMZ) is the current standard chemotherapy for glioma, but tumors usually become resistant and recur. So far, no effective therapy for TMZ-resistant glioma is available. Natural plant antimicrobial solution (PAMs) is a Chinese herbal medicine which has been used for decades without toxicity and has multiple medical functions including anti- inflammatory effects. Here, we report the effects of PAMs on glioblastoma growth. SN - 2662-7671 UR - https://doi.org/10.1186/s12906-020-03041-z DO - 10.1186/s12906-020-03041-z ID - Li2020 ER -