Fig. 3
Modulation of Plasma Bile Acid Metabolism. a Comparison of plasma BAs in the PBC (pretreatment) group to the control group. After statistical analysis, TCDCA, TUDCA, UDCA, GCA, GDCA, GCDCA and TCA were significantly higher in the PBC patients (pretreatment) than the controls (P < 0.05), and the color bars for the BAs in PBC group were browner indicating a higher level. (− 4 < = log2 (x) < = 4. It is obtained from the heat map website: https://www.metaboanalyst.ca/). b Comparison of plasma BAs in the PBC group before (P1–10) and after TN combined with UDCA (P1.1–10.1) compared with the control group (C1–10). After TN combined with UDCA, bile acids had no significant change to pretreatment. The color bars look similar. Visually, this indicated no obvious changes in the metabolism of serum bile acids after TN combined with UDCA. c Comparison of plasma BAs in the PBC group before (P1–10) and after sham-TN with UDCA (P1.1–10.1) with control group (C1–10). After Sham TN combined with UDCA, bile acids had no significant change to pretreatment. The color bars look similar. Visually, this indicated no obvious changes in the metabolism of serum bile acids after sham TN combined with UDCA