Table 5 Previous studies on preclinical antidiabetic potential of myricetin
From: Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications
| Compound / Plant species | Model | Results | Ref. |
|---|---|---|---|
| Myricetin | in vivo | Enhanced enzymatic and non-enzymatic antioxidant defense system and showed protective effects against oxidative damage in liver and kidney of streptozotocin-cadmium-induced diabetic model. | [109] |
| Myricetin | in vivo | Inhibitory activity against α-glucosidase (IC50 = 414 μM) in dose dependent manner. | [110] |
| Myricetin | in vivo | Anti-hyperglycemic and renoprotective effects at 1.0 mg/kg. | [111] |
| Myricetin | in vivo | Improved and re-established renal functions and activities of the glutathione peroxidase and xanthine oxidase enzymes in diabetic rat model. | [112] |
| Myricetin | in vivo | Antidiabetic activity against t-BHP-induced oxidative stress. | [113] |
| Myricetin | in vivo | Reduced glycemia in diabetic rats up to 50% after 2 days of treatment at 3 mg/12 h. | [114] |
| Myricetin | in vivo | Stimulated lipogenesis in rat adipocytes and enhanced the stimulatory effect of insulin (EC50 = 65 μM). | [115] |
| Myricetin | in vitro | Inhibited intestinal α-glucosidase (29%) and porcine α-amylase (64%) with IC50 vale of 0.38 mM. | [116] |
| Abelmoschus moschatus Medik. (aerial part) | in vivo | Improved insulin sensitivity in rats. | [117] |
| Ampelopsis grossedentata (Hand.-Mazz.) W.T. Wang (leaves) | in vivo | Inhibitory activity against α-glucosidase (IC50 = 319.3 μM). | [118] |
| Azadirachta indica A.Juss. (leaves) | in vivo | Enhanced insulin signaling pathway and glucose utilization in skeletal muscle. | [119] |
| Hovenia dulcis Thunb. (seeds) | in vitro | Inhibited intestinal α-glucosidase with IC50 = 3 μg/mL and α-amylase with IC50 = 662 μg/mL. | [120] |
| Myrtus communis L. (leaves) | in vivo | Significant antidiabetic activity in diabetic models. | [121] |
| Syzygium cumini (L.) Skeels (seeds) | in vitro | Inhibitory activity against α-glucosidase (IC50 = 1.7 μg/mL) and α-amylase (IC50 = 7.62 μg/mL). | [122] |
| Syzygium malaccense (L.) Merr. & L.M.Perry (leaves) | in vitro | Inhibitory activity against α-glucosidase (IC50 = 15.52 μg/mL) and α-amylase (IC50 = 147.30 μg/mL). | [123] |
