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Table 3 Antioxidant activities of myricetin

From: Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

Assay Model Results Ref.
Density functional theory in silico The bond dissociation enthalpy computed and the compound showed ionization potentials 161.4 kcal/mol. [64]
Antioxidant response element (ARE) activation in vitro Activates Nrf2 antioxidant response element pathways and is involved in myricetin-induced expression profiling in hepatic cells. [65]
Deoxyribose degradation in vitro Significant antioxidant activity (complex with iron) in the presence of ascorbic acid. [8]
DPPH in vitro Myricetin/HP-β-CD inclusion complex formation enhances antioxidant activity of drugs. [66]
DPPH in vitro Significant RSA dose-dependently [50]
DPPH, ABTS in vitro Inhibition activity from 13.3 to 99.8% at doses of 0.03 to 1 mg/ml during 5 to 20 min. [67]
DPPH, FRAP in vitro High RSA in DPPH assay, and intermediate ferric reducing ability in FRAP assay. [68]
DPPH, FRAP, ABTS in vitro Mean activity for FRAP (27.2, 26.7) mmol Fe2+/L, DPPH (7.9, 9.3) mmol TEAC/L, and ABTS (9.3, 11.5) mmol TEAC/L. [69]
DPPH, FRAP, ORAC in vitro EC50 value of DPPH, FRAP and ORAC assays were recorded as 7.60 μg, 8.86 and 12.99 mmol Trolox equivalents per gram. [70]
DPPH, TPTZ, superoxide in vitro Myricetin and its derivatives showed IC50 value from 1.82 to 3.27 μg/mL in DPPH assay and 1.86 to 3.83 μg/mL in superoxide assay however, 1.38 to 2.89 μM equivalent to Fe2+ /mL for TPTZ assay. [71]
H2O2 in vitro Increases hydrogen peroxide resistance in Saccharomyces cerevisiae. [72]
DPPH, ROS in vitro 21–54% scavenging activity in DPPH assay (5–10 μg/mL) and 35–73% intracellular ROS scavenging activity (1–10 μg/mL). Significantly inhibits H2O2-induced cell death and activated antioxidant enzymes. [73]
NO in vitro Mean scavenging activity compared to hydrophilic antioxidants. [74]
ROS in vitro Inhibits peroxynitrite-mediated DNA damage in primary astrocytes at 5 μM. [75]
ROS in vitro The IC30 value for inhibitory effect on triglyceride and ROS were recorded as > 150 μM and 122.7 μM. [76]
ROS in vitro Inhibits H2O2-induced cell death and increases cell survival (65%). [77]
DCFH-DA in vivo Inhibits ROS production in normal individuals and in patients with sickle cell anemia. [78]
  1. ABTS 2,2′ azino-bis(3-ethylbenzothiazoline-6-sulphonic acid, ARE antioxidant response element, DCFH-DA dichloro-dihydro-fluorescein diacetate, DPPH 2,2-diphenyl-1-picrylhydrazyl, FRAP ferric reducing antioxidant power, NO nitric oxide, ORAC oxygen radical absorbance capacity; ROS reactive oxygen species, RSA radical scavenging activity, TEAC trolox equivalent antioxidant capacity, TPTZ tri-pyridyl triazine