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Table 1 Analgesic activity of Dinaphthodiospyrol G isolated from D. lots

From: In vivo analgesic, anti-inflammatory, and sedative activity and a molecular docking study of dinaphthodiospyrol G isolated from Diospyros lotus

Groups

(Doses mg/kg)

Time (Minutes)

30

60

90

120

Saline

10ā€‰mL/kg

9.21ā€‰Ā±ā€‰0.09

9.19Ā Ā±Ā 0.08

9.20Ā Ā±Ā 0.011

9.18Ā Ā±Ā 0.12

Tramadol

10ā€‰mL/kg

24.61ā€‰Ā±ā€‰0.08***

26.99Ā Ā±Ā 0.98***

25.60Ā Ā±Ā 0.88***

25.00Ā Ā±Ā 0.42***

Chloroform extract

50

8.60ā€‰Ā±ā€‰0.33

8.90Ā Ā±Ā 0.45

8.98Ā Ā±Ā 0.64

8.19Ā Ā±Ā 0.90

100

9.00ā€‰Ā±ā€‰0.54

9.55Ā Ā±Ā 0.52

9.70Ā Ā±Ā 0.70

8.98Ā Ā±Ā 0.80

200

10. 05ā€‰Ā±ā€‰0.20

10.35Ā Ā±Ā 0.50

10.25Ā Ā±Ā 00.55

10.00Ā Ā±Ā 0.40

Dinaphthodiospyrol G

2.5

16.11ā€‰Ā±ā€‰0.44

17.38Ā Ā±Ā 0.67*

16.98Ā Ā±Ā 80

16.77Ā Ā±Ā 1.02

5

17.84ā€‰Ā±ā€‰0.54*

19.01Ā Ā±Ā 0.70**

18.50Ā Ā±Ā 0.88*

18.13Ā Ā±Ā 1.06*

10

19.50ā€‰Ā±ā€‰0.60**

20.97Ā Ā±Ā 0.78**

20.00Ā Ā±Ā 0.80**

19.99Ā Ā±Ā 1.12**

15

21.50ā€‰Ā±ā€‰0.77***

22.98Ā Ā±Ā 0.81***

22.08Ā Ā±Ā 0.95***

21.80Ā Ā±Ā 1.21***

  1. Data expressed as the meanā€‰Ā±ā€‰standard error of the mean (S.E.M.) of latency time in seconds for each group (nā€‰=ā€‰6), statistically, analysis of variance (one way) was done followed by multiple comparison through Dunnettā€™s post-hoc test; Where, pā€‰<ā€‰0.05ā€‰=ā€‰*; pā€‰<ā€‰0.01ā€‰=ā€‰**; pā€‰<ā€‰0.001ā€‰=ā€‰***.