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Table 3 Antimicrobial activity of isolated flavonoid compounds in mg/mL

From: Flavonoids isolated from the South African weed Chromolaena odorata (Asteraceae) have pharmacological activity against uropathogens

Organism

Time (h)

Compounds

 

1

2

3

4

Gent

Cipro

Amp B

S. aureus

–

0.25

0.031

0.016

0.25

0.008

0.063

NA

E. coli (1)

–

0.25

0.031

0.063

0.125

0.016

0.002

NA

E. coli (2)

–

> 0.25

0.031

0.25

> 0.25

0.031

5 × 10−5

NA

E. coli (3)

–

> 0.25

0.031

0.25

> 0.25

0.008

1 × 10−3

NA

K. pneumoniae

–

0.25

0.125

0.125

> 0.25

0.25

0.05

NA

Mean

–

0.25

0.05

0.14

ND

0.06

0.02

NA

SD

–

0

0.04

0.11

ND

0.11

0.03

NA

C. neoformans

48

> 0.25

0.016

> 0.25

> 0.25

NA

NA

0.08

 

72

> 0.25

0.125

> 0.25

> 0.25

NA

NA

0.125

A. fumigatus

48

0.063

0.016

0.031

0.25

NA

NA

0.031

 

72

0.25

0.125

0.25

> 0.25

NA

NA

0.063

 

120

> 2.5

> 2.5

> 2.5

> 2.5

> 2.5

NA

NA

Mean

 

ND

0.07

ND

ND

ND

NA

0.07

SD

 

ND

0.06

ND

ND

ND

NA

0.04

  1. E. coli (1): E. coli (ATTC25922) reference strain; E. coli (2): E. coli (B1989/17) isolate; E. coli (3); E. coli (B1962/17) isolate; Gent = gentamicin; Cipro = ciprofloxacin; Amp B = amphotericin B; 1 = compound 1; 2 = compound 2; 3 = compound 3; 4 = compound 4; NA: not applicable; ND: not detected; SD: standard deviation. Number in bold indicates good antimicrobial activity