Fig. 7

Relative expression (Mean ± SEM) of HIF1α and NFATc2 mRNA (a, c) and protein (b, d) in the lungs of PAH rat models, and the effect of treatment with perillyle alcohol and quercetin. n = 6 in each group. Internal control for HIF1α and NFATc2 mRNA was 18 s rRNA. *and # mean significantly different with control and MCT + Veh respectively. * p < 0.05, ** and ## p < 0.01, *** and ### p < 0.001. CTL, control; MCT, monocrotaline; Veh, vehicle; PA, perillyle alcohol; QS, quercetin; HIF1α, hypoxia-inducible factor 1-alpha; NFATc2, nuclear factor of activated T-cells, cytoplasmic 2