Fig. 3

Representative section of the lung of a normal rat (a), MCT induced PAH (b), MCT + vehicle treatment (c), MCT + PA treatment (d), and MCT + QS treatment (e), and (f) relative quantitative analyses (mean ± SEM) in groups A-E. Normal wall thickness is observed in A, and severe thickening is obvious in B and C. The lung of rats treated with PA and QS show mild thickening of arteriole wall. Here arteriole wall thickness in the CTL group is 14.3 μm, 44 μm in MCT, 43 μm in vehicle, and 18.2 μm and 15.3 μm in PA and QS, respectively. H&E staining; Magnification × 400. n = 6 in each group. Scale bars are 40 μm. *** p < 0.001 vs control, ### p < 0.001 vs MCT + Veh. CTL, control; MCT, monocrotaline; VE, vehicle; PA, perillyle alcohol; QS, quercetin