Skip to main content
Fig. 3 | BMC Complementary Medicine and Therapies

Fig. 3

From: Curcumin inhibits the migration of osteoclast precursors and osteoclastogenesis by repressing CCL3 production

Fig. 3

CCL3 significantly reversed curcumin-reduced osteoclastogenesis. (a) The representative TRAP staining images of differentiated osteoclasts derived from OCPs treated with 25 μM curcumin or PBS in the presence of M-CSF, RANKL and vehicle (DMSO) or three chemokines (10 ng/mL CCL3; 5 ng/mL CCL3; 10 nM CX3CL1) for 5 days. Scale bar, 200 μm. (b-d) The histogram shows the quantitative results regarding mature osteoclasts (more than three nuclei), large osteoclasts (more than five nuclei) or osteoclast size (the ratio of large osteoclasts/total osteoclasts) in A. Data are expressed as mean ± SEM from three independent experiments. lettersP < 0.05 by one-way ANOVA. CUR, curcumin; M, M-CSF; R, RANKL

Back to article page