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Table 3 The effects of the root extract of B. antidysenterica on gastrointestinal fluid accumulation in mice

From: Evaluation of in-vivo antidiarrhoeal and in-vitro antibacterial activities of the root extract of Brucea antidysenterica J. F. Mill (Simaroubaceae)

Extract

Dose Administered

Volume of intestinal contents (mL)

% Inhibition

Weight of intestinal contents (gm)

% Inhibition

80% BAE

DW 10 mL/kg

0.82 ± 0.03

–

1.07 ± 0.04

–

Loperamide 3 mg/kg

0.49 ± 0.04a3c2

39.80

0.71 ± 0.03a2

34.31

BAE 100 mg/kg

0.71 ± 0.03b2e2

13.27

0.90 ± 0.09

16.25

BAE 200 mg/kg

0.57 ± 0.05a3

30.61

0.78 ± 0.06a1

27.82

BAE 400 mg/kg

0.51 ± 0.02a3c2

37.76

0.72 ± 0.06 a2

32.56

  1. Data’s are mean ± SEM (n = 6); a compared with negative control values; b compared with loperamide; c compared with 100 mg/kg; d compared with 200 mg/kg; e compared with 400 mg/kg; 1p < 0.05, 2p < 0.01, 3p < 0.001; DW distilled water, BAE B. antidysenterica extract