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Table 3 The effects of the root extract of B. antidysenterica on gastrointestinal fluid accumulation in mice

From: Evaluation of in-vivo antidiarrhoeal and in-vitro antibacterial activities of the root extract of Brucea antidysenterica J. F. Mill (Simaroubaceae)

Extract Dose Administered Volume of intestinal contents (mL) % Inhibition Weight of intestinal contents (gm) % Inhibition
80% BAE DW 10 mL/kg 0.82 ± 0.03 1.07 ± 0.04
Loperamide 3 mg/kg 0.49 ± 0.04a3c2 39.80 0.71 ± 0.03a2 34.31
BAE 100 mg/kg 0.71 ± 0.03b2e2 13.27 0.90 ± 0.09 16.25
BAE 200 mg/kg 0.57 ± 0.05a3 30.61 0.78 ± 0.06a1 27.82
BAE 400 mg/kg 0.51 ± 0.02a3c2 37.76 0.72 ± 0.06 a2 32.56
  1. Data’s are mean ± SEM (n = 6); a compared with negative control values; b compared with loperamide; c compared with 100 mg/kg; d compared with 200 mg/kg; e compared with 400 mg/kg; 1p < 0.05, 2p < 0.01, 3p < 0.001; DW distilled water, BAE B. antidysenterica extract