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Table 2 The effects of root extract of B. antidysenterica on gastrointestinal transit in mice

From: Evaluation of in-vivo antidiarrhoeal and in-vitro antibacterial activities of the root extract of Brucea antidysenterica J. F. Mill (Simaroubaceae)

Extract Dose Administered Length of small intestine (cm) Distance covered by charcoal meal (cm) Peristaltic index (%) % Inhibition
80% BAE DW 10 mL/kg 57.50 ± 0.43 50.33 ± 0.84 87.56 ± 1.61
Loperamide 3 mg/kg 57.83 ± 0.83 16.50 ± 0.76a3c3d3 28.59 ± 1.50 a3c3d3 67.35
BAE 100 mg/kg 57.83 ± 0.79 30.83 ± 0.67a3b3d3e3 53.30 ± 0.67 a3b3d3e3 39.13
BAE 200 mg/kg 58.33 ± 0.54 22.83 ± 0.84a3b3c3e3 39.11 ± 1.18 a3b3c3e3 55.34
BAE 400 mg/kg 56.83 ± 0.48 16.17 ± 1.19a3c3d3 28.38 ± 1.87 a3c3d3 67.59
  1. Data’s are mean ± SEM (n = 6); a compared with negative control values; b compared with loperamide; c compared with 100 mg/kg; d compared with 200 mg/kg; e compared with 400 mg/kg; 1p < 0.05, 2p < 0.01, 3p < 0.001; DW distilled water, BAE B. antidysenterica extract