Evaluation of in-vivo antidiarrhoeal and in-vitro antibacterial activities of the root extract of Brucea antidysenterica J. F. Mill (Simaroubaceae)

Table 2 The effects of root extract of B. antidysenterica on gastrointestinal transit in mice

Extract	Dose Administered	Length of small intestine (cm)	Distance covered by charcoal meal (cm)	Peristaltic index (%)	% Inhibition
80% BAE	DW 10 mL/kg	57.50 ± 0.43	50.33 ± 0.84	87.56 ± 1.61	–
	Loperamide 3 mg/kg	57.83 ± 0.83	16.50 ± 0.76^a3c3d3	28.59 ± 1.50 ^a3c3d3	67.35
	BAE 100 mg/kg	57.83 ± 0.79	30.83 ± 0.67^a3b3d3e3	53.30 ± 0.67 ^a3b3d3e3	39.13
	BAE 200 mg/kg	58.33 ± 0.54	22.83 ± 0.84^a3b3c3e3	39.11 ± 1.18 ^a3b3c3e3	55.34
	BAE 400 mg/kg	56.83 ± 0.48	16.17 ± 1.19^a3c3d3	28.38 ± 1.87 ^a3c3d3	67.59

Data’s are mean ± SEM (n = 6); ^a compared with negative control values; ^b compared with loperamide; ^c compared with 100 mg/kg; ^d compared with 200 mg/kg; ^e compared with 400 mg/kg; ¹p < 0.05, ²p < 0.01, ³p < 0.001; DW distilled water, BAE B. antidysenterica extract

ISSN: 2662-7671