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Table 1 The Antidiarrhoeal effects of the root extract of B. antidysenterica on castor oil-induced diarrhoeal model in mice

From: Evaluation of in-vivo antidiarrhoeal and in-vitro antibacterial activities of the root extract of Brucea antidysenterica J. F. Mill (Simaroubaceae)

  Dose Administered Onset of Diarrhoea (Min) No of wet faeces Total No of faeces Average weight of wet faeces (gm) Average weight of total faeces (gm) % Reduction
80% BAE DW 10 mL/kg 76.17 ± 2.07 7.5 ± 0.43 8.17 ± 0.48 0.76 ± 0.04 0.83 ± 0.05
Loperamide 3 mg/kg 166.33 ± 6.97a3c3 1.33 ± 0.33a3c3 2.67 ± 0.42a3c2 0.14 ± 0.03a3c2 0.23 ± 0.05a3c2 82.22%
BAE 100 mg/kg 89.50 ± 2.50b3d3e3 3.5 ± 0.22a3b3d3e3 4.83 ± 0.31a3b2e2 0.38 ± 0.04 a3b2d1e3 0.50 ± 0.05a3b2e2 53.33%
BAE 200 mg/kg 151.00 ± 3.17a3c3e2 1.33 ± 0.21a3c3 3.33 ± 0.33a3 0.18 ± 0.03 a3c1 0.31 ± 0.04a3 82.22%
BAE 400 mg/kg 172.67 ± 3.48a3c3d2 0.83 ± 0.31a3c3 2.17 ± 0.40a3c2 0.11 ± 0.04 a3c3 0.19 ± 0.05a3c2 88.89%
  1. Data’s are mean ± SEM (n = 6); a compared with negative control values; b compared with loperamide; c compared with 100 mg/kg; d compared with 200 mg/kg; e compared with 400 mg/kg; 1p < 0.05, 2p < 0.01, 3p < 0.001; DW Distilled water, BAE B. antidysenterica extract