Evaluation of in-vivo antidiarrhoeal and in-vitro antibacterial activities of the root extract of Brucea antidysenterica J. F. Mill (Simaroubaceae)

Table 1 The Antidiarrhoeal effects of the root extract of B. antidysenterica on castor oil-induced diarrhoeal model in mice

	Dose Administered	Onset of Diarrhoea (Min)	No of wet faeces	Total No of faeces	Average weight of wet faeces (gm)	Average weight of total faeces (gm)	% Reduction
80% BAE	DW 10 mL/kg	76.17 ± 2.07	7.5 ± 0.43	8.17 ± 0.48	0.76 ± 0.04	0.83 ± 0.05	–
	Loperamide 3 mg/kg	166.33 ± 6.97^a3c3	1.33 ± 0.33^a3c3	2.67 ± 0.42^a3c2	0.14 ± 0.03^a3c2	0.23 ± 0.05^a3c2	82.22%
	BAE 100 mg/kg	89.50 ± 2.50^b3d3e3	3.5 ± 0.22^a3b3d3e3	4.83 ± 0.31^a3b2e2	0.38 ± 0.04 ^a3b2d1e3	0.50 ± 0.05^a3b2e2	53.33%
	BAE 200 mg/kg	151.00 ± 3.17^a3c3e2	1.33 ± 0.21^a3c3	3.33 ± 0.33^a3	0.18 ± 0.03 ^a3c1	0.31 ± 0.04^a3	82.22%
	BAE 400 mg/kg	172.67 ± 3.48^a3c3d2	0.83 ± 0.31^a3c3	2.17 ± 0.40^a3c2	0.11 ± 0.04 ^a3c3	0.19 ± 0.05^a3c2	88.89%

Data’s are mean ± SEM (n = 6); ^a compared with negative control values; ^b compared with loperamide; ^c compared with 100 mg/kg; ^d compared with 200 mg/kg; ^e compared with 400 mg/kg; ¹p < 0.05, ²p < 0.01, ³p < 0.001; DW Distilled water, BAE B. antidysenterica extract

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