From: Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats
Organs | Units | Male dose (mg/kg/day) | Female dose (mg/kg/day) | ||||||
---|---|---|---|---|---|---|---|---|---|
0b | 800 | 2000 | 5000 | 0b | 800 | 2000 | 5000 | ||
Body weightc | g | 532.6 ± 59.9 | 470.0 ± 36.2* | 512.1 ± 44 | 508.5 ± 42.8 | 314.6 ± 31.3 | 262.2 ± 13.6** | 263.0 ± 23.4** | 252.9 ± 18.9** |
Brain | g | 2.10 ± 0.07 | 2.10 ± 0.07 | 2.14 ± 0.11 | 2.12 ± 0.06 | 1.94 ± 0.08 | 1.93 ± 0.09 | 1.95 ± 0.08 | 1.93 ± 0.07 |
g/100 g BW | 0.40 ± 0.04 | 0.45 ± 0.03** | 0.42 ± 0.03 | 0.42 ± 0.03 | 0.62 ± 0.08 | 0.74 ± 0.04** | 0.75 ± 0.08** | 0.77 ± 0.07** | |
Pituitary | mg | 12.8 ± 1.9 | 11.1 ± 0.8 | 12.1 ± 1.5 | 13.6 ± 2.0 | 16.9 ± 2.8 | 14.9 ± 1.7 | 13.7 ± 1.7** | 13.8 ± 1.8** |
mg/100 g BW | 2.4 ± 0.2 | 2.4 ± 0.3 | 2.4 ± 0.3 | 2.7 ± 0.4 | 5.4 ± 1.0 | 5.7 ± 0.6 | 5.2 ± 0.7 | 5.4 ± 0.6 | |
Heart | g | 1.49 ± 0.16 | 1.28 ± 0.10** | 1.39 ± 0.18 | 1.43 ± 0.10 | 0.99 ± 0.09 | 0.87 ± 0.10* | 0.92 ± 0.06 | 0.93 ± 0.10 |
g/100 g BW | 0.28 ± 0.02 | 0.27 ± 0.01 | 0.27 ± 0.03 | 0.28 ± 0.02 | 0.32 ± 0.02 | 0.33 ± 0.03 | 0.35 ± 0.03* | 0.37 ± 0.03** | |
Lung | g | 1.54 ± 0.14 | 1.53 ± 0.10 | 1.60 ± 0.13 | 1.54 ± 0.09 | 1.25 ± 0.07 | 1.16 ± 0.07* | 1.18 ± 0.10 | 1.16 ± 0.09* |
g/100 g BW | 0.29 ± 0.02 | 0.32 ± 0.02* | 0.31 ± 0.03 | 0.30 ± 0.03 | 0.40 ± 0.04 | 0.45 ± 0.03* | 0.45 ± 0.04** | 0.46 ± 0.02** | |
Liver | g | 13.87 ± 2.06 | 11.99 ± 1.28 | 14.36 ± 2.05 | 15.81 ± 1.90 | 7.67 ± 0.67 | 7.37 ± 0.83 | 7.89 ± 0.64 | 8.39 ± 0.74 |
g/100 g BW | 2.60 ± 0.15 | 2.55 ± 0.18 | 2.80 ± 0.22 | 3.10 ± 0.19** | 2.45 ± 0.23 | 2.81 ± 0.26* | 3.01 ± 0.29** | 3.32 ± 0.28** | |
Spleen | g | 0.92 ± 0.10 | 0.79 ± 0.12 | 0.85 ± 0.12 | 0.86 ± 0.09 | 0.55 ± 0.08 | 0.51 ± 0.06 | 0.54 ± 0.05 | 0.55 ± 0.09 |
g/100 g BW | 0.17 ± 0.02 | 0.17 ± 0.02 | 0.17 ± 0.02 | 0.17 ± 0.03 | 0.18 ± 0.03 | 0.20 ± 0.01 | 0.21 ± 0.02* | 0.22 ± 0.03** | |
Kidney | g | 3.24 ± 0.45 | 2.98 ± 0.36 | 3.25 ± 0.33 | 3.69 ± 0.41* | 1.91 ± 0.17 | 1.77 ± 0.13 | 1.92 ± 0.22 | 1.79 ± 0.12 |
g/100 g BW | 0.61 ± 0.05 | 0.63 ± 0.06 | 0.64 ± 0.04 | 0.73 ± 0.06** | 0.62 ± 0.08 | 0.68 ± 0.05 | 0.74 ± 0.13 | 0.71 ± 0.04# | |
Adrenal | mg | 61.9 ± 8.0 | 53.7 ± 7.3 | 57.1 ± 6.8 | 69.1 ± 17.1 | 65.1 ± 9.0 | 72.1 ± 16.9 | 81.9 ± 11.9 | 72.3 ± 19.4 |
mg/100 g BW | 11.8 ± 2.2 | 11.5 ± 1.8 | 11.3 ± 1.8 | 13.5 ± 2.8 | 20.9 ± 3.7 | 27.4 ± 5.1* | 31.5 ± 6.2** | 28.5 ± 7.0* |