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Table 9 Summary of selecteda absolute and relative organ weights in the subchronic toxicity study of HT047

From: Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats

Organs

Units

Male dose (mg/kg/day)

Female dose (mg/kg/day)

0b

800

2000

5000

0b

800

2000

5000

Body weightc

g

532.6 ± 59.9

470.0 ± 36.2*

512.1 ± 44

508.5 ± 42.8

314.6 ± 31.3

262.2 ± 13.6**

263.0 ± 23.4**

252.9 ± 18.9**

Brain

g

2.10 ± 0.07

2.10 ± 0.07

2.14 ± 0.11

2.12 ± 0.06

1.94 ± 0.08

1.93 ± 0.09

1.95 ± 0.08

1.93 ± 0.07

g/100 g BW

0.40 ± 0.04

0.45 ± 0.03**

0.42 ± 0.03

0.42 ± 0.03

0.62 ± 0.08

0.74 ± 0.04**

0.75 ± 0.08**

0.77 ± 0.07**

Pituitary

mg

12.8 ± 1.9

11.1 ± 0.8

12.1 ± 1.5

13.6 ± 2.0

16.9 ± 2.8

14.9 ± 1.7

13.7 ± 1.7**

13.8 ± 1.8**

mg/100 g BW

2.4 ± 0.2

2.4 ± 0.3

2.4 ± 0.3

2.7 ± 0.4

5.4 ± 1.0

5.7 ± 0.6

5.2 ± 0.7

5.4 ± 0.6

Heart

g

1.49 ± 0.16

1.28 ± 0.10**

1.39 ± 0.18

1.43 ± 0.10

0.99 ± 0.09

0.87 ± 0.10*

0.92 ± 0.06

0.93 ± 0.10

g/100 g BW

0.28 ± 0.02

0.27 ± 0.01

0.27 ± 0.03

0.28 ± 0.02

0.32 ± 0.02

0.33 ± 0.03

0.35 ± 0.03*

0.37 ± 0.03**

Lung

g

1.54 ± 0.14

1.53 ± 0.10

1.60 ± 0.13

1.54 ± 0.09

1.25 ± 0.07

1.16 ± 0.07*

1.18 ± 0.10

1.16 ± 0.09*

g/100 g BW

0.29 ± 0.02

0.32 ± 0.02*

0.31 ± 0.03

0.30 ± 0.03

0.40 ± 0.04

0.45 ± 0.03*

0.45 ± 0.04**

0.46 ± 0.02**

Liver

g

13.87 ± 2.06

11.99 ± 1.28

14.36 ± 2.05

15.81 ± 1.90

7.67 ± 0.67

7.37 ± 0.83

7.89 ± 0.64

8.39 ± 0.74

g/100 g BW

2.60 ± 0.15

2.55 ± 0.18

2.80 ± 0.22

3.10 ± 0.19**

2.45 ± 0.23

2.81 ± 0.26*

3.01 ± 0.29**

3.32 ± 0.28**

Spleen

g

0.92 ± 0.10

0.79 ± 0.12

0.85 ± 0.12

0.86 ± 0.09

0.55 ± 0.08

0.51 ± 0.06

0.54 ± 0.05

0.55 ± 0.09

g/100 g BW

0.17 ± 0.02

0.17 ± 0.02

0.17 ± 0.02

0.17 ± 0.03

0.18 ± 0.03

0.20 ± 0.01

0.21 ± 0.02*

0.22 ± 0.03**

Kidney

g

3.24 ± 0.45

2.98 ± 0.36

3.25 ± 0.33

3.69 ± 0.41*

1.91 ± 0.17

1.77 ± 0.13

1.92 ± 0.22

1.79 ± 0.12

g/100 g BW

0.61 ± 0.05

0.63 ± 0.06

0.64 ± 0.04

0.73 ± 0.06**

0.62 ± 0.08

0.68 ± 0.05

0.74 ± 0.13

0.71 ± 0.04#

Adrenal

mg

61.9 ± 8.0

53.7 ± 7.3

57.1 ± 6.8

69.1 ± 17.1

65.1 ± 9.0

72.1 ± 16.9

81.9 ± 11.9

72.3 ± 19.4

mg/100 g BW

11.8 ± 2.2

11.5 ± 1.8

11.3 ± 1.8

13.5 ± 2.8

20.9 ± 3.7

27.4 ± 5.1*

31.5 ± 6.2**

28.5 ± 7.0*

  1. a Only parameters with statistical significance are shown in table
  2. b Distilled water (10 mL/kg/day)
  3. c Fasting weight on the 92nd day before sacrifice. BW, body weight
  4. * p < 0.05 and ** p < 0.01 vs. control by one-way ANOVA with post-hoc Dunnett’s t-test
  5. # p < 0.05 vs. control by Kruskal-Wallis test with post-hoc Steel's test
  6. Data are presented as mean ± SD (n = 10 per group)