Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats

Table 7 Summary of selected^a hematological findings after 13-week administration of HT047

Parameters	Units	Male dose (mg/kg/day)				Female dose (mg/kg/day)
Parameters	Units	0^b	800	2000	5000	0^b	800	2000	5000
RBC	× 10⁶ cells/μL	8.72 ± 0.25	8.80 ± 0.41	8.81 ± 0.36	8.58 ± 0.35	7.95 ± 0.37	7.85 ± 0.32	7.93 ± 0.42	7.42 ± 0.53^*
Hemoglobin	g/dL	15.1 ± 0.3	15.4 ± 0.7	15.4 ± 0.3	15.3 ± 0.5	14.6 ± 0.7	14.7 ± 0.3	14.6 ± 0.9	13.7 ± 0.6^#
Hematocrit	%	45.3 ± 1.2	46.2 ± 1.9	45.6 ± 1.8	45.4 ± 1.6	42.4 ± 2.2	42.1 ± 1.2	41.8 ± 2.6	39.5 ± 2.0^**
Reticulocytes	%	2.73 ± 0.46	2.19 ± 0.54^*	2.21 ± 0.31^*	2.13 ± 0.36^**	2.05 ± 0.35	2.17 ± 0.3	1.86 ± 0.29	2.29 ± 0.63
Neutrophils	%	20.7 ± 6.6	19.1 ± 6.8	17.4 ± 4.4	16.3 ± 6.2	19.2 ± 6.0	13.0 ± 4.2^*	18.4 ± 5.4	13.7 ± 3.1^*
Lymphocytes	%	74.7 ± 6.7	76.6 ± 6.5	78.5 ± 4.7	79.6 ± 6.5	75.6 ± 6.1	83.5 ± 4.4^**	76.9 ± 5.5	82.6 ± 3.5^**
Monocytes	%	2.3 ± 0.5	2.0 ± 1.0	1.8 ± 0.6	1.8 ± 0.5	2.4 ± 0.8	1.5 ± 0.5^*	1.9 ± 0.9	1.6 ± 0.5^*
Eosinophils	%	1.2 ± 0.2	1.0 ± 0.4	1.3 ± 0.2	0.8 ± 0.2^##	1.7 ± 0.5	1.1 ± 0.3	1.6 ± 0.8	1.0 ± 0.3^#
Prothrombin time	sec	17.8 ± 0.4	18.0 ± 0.4	18.0 ± 1.0	19.5 ± 1.1^##	17.3 ± 0.7	18.7 ± 1.0^**	18.6 ± 1.2^**	19.0 ± 0.7^**

^a Only parameters with statistical significance are shown in table. RBC, red blood cell
^b Distilled water (10 mL/kg/day)
* p < 0.05 and ** p < 0.01 vs. control by one-way ANOVA with post-hoc Dunnett’s t-test
# p < 0.05 and ## p < 0.01 vs. control by Kruskal-Wallis test with post-hoc Steel's test
Data are presented as mean ± SD (n = 10 per group)

ISSN: 2662-7671