Table 6 Urinalysis findings after 13-week administration of HT047
From: Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats
Parameters | Results | Male dose (mg/kg/day) | Female dose (mg/kg/day) | ||||||
|---|---|---|---|---|---|---|---|---|---|
0a | 800 | 2000 | 5000 | 0a | 800 | 2000 | 5000 | ||
Color | Pale yellow | 5b | 1 | 0 | 0 | 3 | 3 | 0 | 0 |
Yellow | 5 | 9 | 10 | 10 | 7 | 7 | 9 | 7 | |
Amber | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | |
Transparency | Clear | 10 | 10 | 10 | 10 | 10 | 8 | 5 | 4 |
Mild turbidity | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 1 | |
Turbidity | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5 | |
pH | 7 | 3 | 0 | 3 | 0 | 3 | 0 | 2 | 0 |
8 | 7 | 10 | 6 | 9 | 6 | 7 | 5 | 5 | |
9 | 0 | 0 | 1 | 1 | 1 | 3 | 3 | 5 | |
Protein | Negative | 9 | 9 | 5 | 6 | 8 | 8 | 8 | 4 |
25 mg/dL | 1 | 1 | 4 | 4 | 2 | 1 | 2 | 6 | |
75 mg/dL | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
150 mg/dL | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | |
Glucose | Normal | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
Ketone body | Negative | 6 | 6 | 2 | 0 | 6 | 7 | 1 | 0 |
5 mg/dL | 4 | 3 | 6 | 3 | 4 | 1 | 6 | 5 | |
15 mg/dL | 0 | 1 | 2 | 5 | 0 | 2 | 2 | 5 | |
50 mg/dL | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | |
Bilirubin | Negative | 10 | 10 | 10 | 10 | 9 | 9 | 9 | 10 |
1 mg/dL | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | |
Occult blood | Negative | 9 | 10 | 9 | 10 | 10 | 10 | 10 | 9 |
10 Ery/μL | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
50 Ery/μL | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | |
Specific gravity | 1.000 ~ 1.010 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
1.021 ~ 1.030 | 0 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | |
1.031 ~ 1.040 | 1 | 3 | 4 | 0 | 0 | 2 | 4 | 3 | |
1.041 ~ 1.050 | 6 | 2 | 3 | 2 | 6 | 2 | 3 | 0 | |
1.051 ~ 1.060 | 3 | 5 | 1 | 3 | 2 | 1 | 0 | 5 | |
> 1.060 | 0 | 0 | 1 | 4 | 1 | 2 | 2 | 1 | |