Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats

Song, Jungbin; Kim, Young-Sik; Lee, Donghun; Kim, Hocheol

doi:10.1186/s12906-020-02998-1

BMC Complementary Medicine and Therapies

Table 2 Body weight changes during the 13-week administration of HT047

From: Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats

Weeks	Male dose (mg/kg/day)				Female dose (mg/kg/day)
Weeks	0^a	800	2000	5000	0^a	800	2000	5000
0^b	188.1 ± 5.2^c	188.1 ± 6.2	189.4 ± 10.1	188.9 ± 6.1	172.5 ± 6.6	171.8 ± 8.6	172.7 ± 10.5	169.9 ± 8.1
1	252.9 ± 10.9	251.1 ± 10.8	254.0 ± 13.8	252.2 ± 9.9	196.8 ± 10	190.3 ± 10.1	190.6 ± 10.5	186.6 ± 9.8
2	309.5 ± 17.9	304.3 ± 22.0	311.0 ± 18.7	310.1 ± 11.5	219.3 ± 13.9	209.9 ± 9.6	204.1 ± 10.0^*	203.6 ± 15.3^**
3	351.6 ± 25.4	341.2 ± 30.0	354.1 ± 26.9	354.0 ± 17.7	239.9 ± 17.4	225.1 ± 14.4	215.3 ± 16.1^**	217.2 ± 18.2^**
4	388.2 ± 30.8	370.0 ± 34.2	387.6 ± 30.2	389.5 ± 22.9	261.8 ± 18.6	235 ± 10.1^**	226.6 ± 15.6^**	226.3 ± 15.9^**
5	421.3 ± 34.6	394.7 ± 32.4	420.4 ± 32.8	424.1 ± 26.3	277.5 ± 20.3	246.1 ± 12.5^**	236.3 ± 15.9^**	238.9 ± 19.4^**
6	448.8 ± 37.8	419.4 ± 36.5	448.7 ± 32.2	449.3 ± 31.9	292.6 ± 23.4	254.4 ± 14.7^**	248.5 ± 13.6^**	246.9 ± 21^**
7	470.0 ± 44.6	438.5 ± 37.0	474.3 ± 30.8	473.2 ± 35.2	302.2 ± 26.1	262.5 ± 14.6^**	258.9 ± 15.0^**	255.5 ± 19.8^**
8	492.6 ± 47.1	454.2 ± 39.3	491.2 ± 32.4	490.8 ± 38.7	310.4 ± 25.9	264.9 ± 12.9^**	263.6 ± 17.4^**	259.4 ± 21.8^**
9	511.5 ± 49.7	465.4 ± 38.3*	510.6 ± 34.0	505.3 ± 42.9	316.4 ± 28.2	271.1 ± 15.8^**	266.2 ± 19.5^**	260.9 ± 22.7^**
10	526.1 ± 52.8	473.7 ± 38.1*	520.0 ± 37.7	513.4 ± 45.9	319.9 ± 29.6	274.6 ± 15.5^**	272.6 ± 20.5^**	264.3 ± 22.8^**
11	538.4 ± 57.7	484.5 ± 37.5	527.2 ± 43.0	523.0 ± 47.1	326.4 ± 30.7	275.2 ± 13.7^**	277.2 ± 22.5^**	266.4 ± 21^**
12	551.6 ± 59.4	492.3 ± 37.2^*	534.8 ± 44.2	531.8 ± 50.0	328.1 ± 32.1	278.8 ± 15.7^**	281.6 ± 21.5^**	269.6 ± 22.8^**
13	553.5 ± 59.4	496.5 ± 38.2	540.8 ± 46.7	535.8 ± 50.9	329.7 ± 30.6	281.5 ± 14.5^**	282.0 ± 24.5^**	272.0 ± 22.7^**

^a Distilled water (10 mL/kg/day)
^b The day of first treatment was designated week 0
^c Data are expressed as mean ± SD in grams (n = 15 for the control and 5000 mg/kg/day groups; n = 10 for the 800 and 2000 mg/kg/day groups)
* p < 0.05 and ** p < 0.01 vs. control by one-way ANOVA with post-hoc Dunnett’s t-test

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