Fig. 4

Change trends of twenty-three significantly differential metabolites identified in both cell lines between control groups, middle dose groups, and high dose groups. The solid line represents the result of MDA-MB-468 cell line; the dotted line is on behalf of the result of MDA-MB-231 cell line. The symbol of “*” indicates that the EECR treatment groups are compared statistically with the control groups. The symbol of “^#” means that the high dose groups are compared statistically with the middle dose groups. The result were given as mean ± SD, n = 9, *p < 0.05, **p < 0.01, ***p < 0.001; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001