Table 4 GRADE for quality of evidence profile
Study ID | Outcomes (number of studies) | Risk of bias | Inconsistency | Indirectness. | Imprecision | Publication bias | Quality of evidence |
|---|---|---|---|---|---|---|---|
Xu 2008 [20] | NIP (10) | Seriousa | Not serious | Not serious | Not serious | Undetected | Moderate |
NRP (4) | Seriousa | Not serious | Not serious | Not serious | Undetected | Moderate | |
MS (3) | Seriousa | Not serious | Not serious | Not serious | Undetected | Moderate | |
PJ (3) | Seriousa | Seriousc | Not serious | Not serious | Undetected | Low | |
ESR (4) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate | |
SJ (4) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
GS (3) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
CPR (3) | Serious a | Not serious | Not serious | Seriousd | Undetected | Low | |
ADEs (4) | Serious a | Not serious | Not serious | Seriousd | Undetected | Low | |
Qi 2010 [29] | MS (3) | Serious a | Not serious | Not serious | Seriousd | Undetected | Low |
SJ (3) | Serious a | Seriousc | Not serious | Seriousd | Undetected | Very low | |
PJ (2) | Serious a | Not serious | Not serious | Seriousd | Undetected | Low | |
ESR (2) | Serious a | Not serious | Not serious | Seriousd | Undetected | Low | |
RF (2) | Serious a | Seriousc | Not serious | Seriousd | Undetected | Very low | |
Zhang 2012 [30] | ACR (2) | Serious a | Seriousc | Not serious | Not serious | Strongly suspectedb | Very low |
PJ (8) | Serious a | Seriousc | Not serious | Not serious | Strongly suspectedb | Very low | |
SJ (8) | Serious a | Seriousc | Not serious | Not serious | Strongly suspectedb | Very low | |
ESR (9) | Serious a | Seriousc | Not serious | Not serious | Strongly suspectedb | Very low | |
CPR (7) | Serious a | Not serious | Not serious | Not serious | Strongly suspectedb | Low | |
RF (9) | Serious a | Not serious | Not serious | Not serious | Strongly suspectedb | Low | |
Li 2012 [31] | Total Effect (6) | Serious a | Not serious | Not serious | Not serious | Strongly suspectedb | Low |
MS (3) | Serious a | Not serious | Not serious | Seriousd | Strongly suspectedb | Very low | |
ESR (5) | Serious a | Not serious | Not serious | Not serious | Strongly suspectedb | Low | |
RF (5) | Serious a | Not serious | Not serious | Not serious | Strongly suspectedb | Low | |
CRP (8) | Serious a | Not serious | Not serious | Not serious | Strongly suspectedb | Low | |
Wang 2015 [32] | Total Effect (6) | Serious a | Not serious | Not serious | Not serious | Strongly suspectedb | Low |
MS (5) | Serious a | Seriousc | Not serious | Not serious | Strongly suspectedb | Very low | |
ESR (6) | Serious a | Seriousc | Not serious | Not serious | Strongly suspectedb | Very low | |
RF (6) | Serious a | Seriousc | Not serious | Not serious | Strongly suspectedb | Very low | |
CPR (6) | Serious a | Not serious | Not serious | Seriousd | Strongly suspectedb | Very low | |
ADEs (5) | Serious a | Not serious | Not serious | Not serious | Strongly suspectedb | Low | |
Chen 2015 [34] | Total Effect of ZQFTN (11) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low |
RF (8) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
ESR (10) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
CRP (8) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
D MS (6) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
SJC (6) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate | |
TGC (7) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate | |
ADEs (10) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate | |
Li 2016 [33] | Total Effect of ZQFTN (8) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate |
MS (8) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
PJ (8) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
GS (8) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
SJ (8) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
ESR (8) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
RF (8) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
CPR (8) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
AD (8) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate | |
Liu 2016 [21] | Clinical efficacy (15) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate |
Publication bias (15) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate | |
Subgroup analysis (15) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate | |
Sensitivity analysis (15) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate | |
Total clinical effective rate in 4 weeks treatment (2) | Serious a | Seriousc | Not serious | Seriousd | Undetected | Very low | |
MS (12) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
SJ (9) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
GS (6) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
ESR (12) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
CRP (11) | Serious a | Seriousc | Not serious | Not serious | Undetected | Low | |
PLT (2) | Serious a | Not serious | Not serious | Seriousd | Undetected | Low | |
DAS28(4) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate | |
ADEs (12) | Serious a | Not serious | Not serious | Not serious | Undetected | Moderate |