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Table 4 GRADE for quality of evidence profile

From: Methodological and reporting quality evaluation of meta-analyses on the Chinese herbal preparation Zheng Qing Feng Tong Ning for the treatment of rheumatoid arthritis

Study IDOutcomes (number of studies)Risk of biasInconsistencyIndirectness.ImprecisionPublication biasQuality of evidence
Xu 2008 [20]NIP (10)SeriousaNot seriousNot seriousNot seriousUndetectedModerate
NRP (4)SeriousaNot seriousNot seriousNot seriousUndetectedModerate
MS (3)SeriousaNot seriousNot seriousNot seriousUndetectedModerate
PJ (3)SeriousaSeriouscNot seriousNot seriousUndetectedLow
ESR (4)Serious aNot seriousNot seriousNot seriousUndetectedModerate
SJ (4)Serious aSeriouscNot seriousNot seriousUndetectedLow
GS (3)Serious aSeriouscNot seriousNot seriousUndetectedLow
CPR (3)Serious aNot seriousNot seriousSeriousdUndetectedLow
ADEs (4)Serious aNot seriousNot seriousSeriousdUndetectedLow
Qi 2010 [29]MS (3)Serious aNot seriousNot seriousSeriousdUndetectedLow
SJ (3)Serious aSeriouscNot seriousSeriousdUndetectedVery low
PJ (2)Serious aNot seriousNot seriousSeriousdUndetectedLow
ESR (2)Serious aNot seriousNot seriousSeriousdUndetectedLow
RF (2)Serious aSeriouscNot seriousSeriousdUndetectedVery low
Zhang 2012 [30]ACR (2)Serious aSeriouscNot seriousNot seriousStrongly suspectedbVery low
PJ (8)Serious aSeriouscNot seriousNot seriousStrongly suspectedbVery low
SJ (8)Serious aSeriouscNot seriousNot seriousStrongly suspectedbVery low
ESR (9)Serious aSeriouscNot seriousNot seriousStrongly suspectedbVery low
CPR (7)Serious aNot seriousNot seriousNot seriousStrongly suspectedbLow
RF (9)Serious aNot seriousNot seriousNot seriousStrongly suspectedbLow
Li 2012 [31]Total Effect (6)Serious aNot seriousNot seriousNot seriousStrongly suspectedbLow
MS (3)Serious aNot seriousNot seriousSeriousdStrongly suspectedbVery low
ESR (5)Serious aNot seriousNot seriousNot seriousStrongly suspectedbLow
RF (5)Serious aNot seriousNot seriousNot seriousStrongly suspectedbLow
CRP (8)Serious aNot seriousNot seriousNot seriousStrongly suspectedbLow
Wang 2015 [32]Total Effect (6)Serious aNot seriousNot seriousNot seriousStrongly suspectedbLow
MS (5)Serious aSeriouscNot seriousNot seriousStrongly suspectedbVery low
ESR (6)Serious aSeriouscNot seriousNot seriousStrongly suspectedbVery low
RF (6)Serious aSeriouscNot seriousNot seriousStrongly suspectedbVery low
CPR (6)Serious aNot seriousNot seriousSeriousdStrongly suspectedbVery low
ADEs (5)Serious aNot seriousNot seriousNot seriousStrongly suspectedbLow
Chen 2015 [34]Total Effect of ZQFTN (11)Serious aSeriouscNot seriousNot seriousUndetectedLow
RF (8)Serious aSeriouscNot seriousNot seriousUndetectedLow
ESR (10)Serious aSeriouscNot seriousNot seriousUndetectedLow
CRP (8)Serious aSeriouscNot seriousNot seriousUndetectedLow
D MS (6)Serious aSeriouscNot seriousNot seriousUndetectedLow
SJC (6)Serious aNot seriousNot seriousNot seriousUndetectedModerate
TGC (7)Serious aNot seriousNot seriousNot seriousUndetectedModerate
ADEs (10)Serious aNot seriousNot seriousNot seriousUndetectedModerate
Li 2016 [33]Total Effect of ZQFTN (8)Serious aNot seriousNot seriousNot seriousUndetectedModerate
MS (8)Serious aSeriouscNot seriousNot seriousUndetectedLow
PJ (8)Serious aSeriouscNot seriousNot seriousUndetectedLow
GS (8)Serious aSeriouscNot seriousNot seriousUndetectedLow
SJ (8)Serious aSeriouscNot seriousNot seriousUndetectedLow
ESR (8)Serious aSeriouscNot seriousNot seriousUndetectedLow
RF (8)Serious aSeriouscNot seriousNot seriousUndetectedLow
CPR (8)Serious aSeriouscNot seriousNot seriousUndetectedLow
AD (8)Serious aNot seriousNot seriousNot seriousUndetectedModerate
Liu 2016 [21]Clinical efficacy (15)Serious aNot seriousNot seriousNot seriousUndetectedModerate
Publication bias (15)Serious aNot seriousNot seriousNot seriousUndetectedModerate
Subgroup analysis (15)Serious aNot seriousNot seriousNot seriousUndetectedModerate
Sensitivity analysis (15)Serious aNot seriousNot seriousNot seriousUndetectedModerate
Total clinical effective rate in 4 weeks treatment (2)Serious aSeriouscNot seriousSeriousdUndetectedVery low
MS (12)Serious aSeriouscNot seriousNot seriousUndetectedLow
SJ (9)Serious aSeriouscNot seriousNot seriousUndetectedLow
GS (6)Serious aSeriouscNot seriousNot seriousUndetectedLow
ESR (12)Serious aSeriouscNot seriousNot seriousUndetectedLow
CRP (11)Serious aSeriouscNot seriousNot seriousUndetectedLow
PLT (2)Serious aNot seriousNot seriousSeriousdUndetectedLow
DAS28(4)Serious aNot seriousNot seriousNot seriousUndetectedModerate
ADEs (12)Serious aNot seriousNot seriousNot seriousUndetectedModerate
  1. Abbreviations:SIN Sinomenine preparations, NSAIDs Non-steroidal anti-inflammatory drugs, NIP Number of improved patients, NRP Number of rheumatoid-factor-disappeared patients, MS Morning stiffness, PJ Painful joint, SJ Swollen joint, SJC Swollen Joint Count, GS Grip strength, ESR Erythrocyte sedimentation rate, CRP C-reactive protein, AD Adverse effects, JTS Joint tenderness score, AI Articular index, ZQFTN Zhengqing Fengtongning release tablets, MTX Methotrexate, DMS Duration of morning stiffness, TGC Tender Joint Count, ADEs Adverse Effects, PLT Blood platelet, DAS28 Disease activity score for rheumatoid arthritis in 28 Joints
  2. a(Unclear random sequence generation, allocation concealment blinding not done in all studies)
  3. b(Incomplete retrieval for unpublished studies and gray literature, evidence for publication bias was underpowered)
  4. c(The overlap degree of different research confidence intervals is poor, and I2 > 50%)
  5. d(Inadequate sample size and the wide 95% (CI))