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Fig. 2 | BMC Complementary Medicine and Therapies

Fig. 2

From: Endothelium-dependent and endothelium-independent vasorelaxant effects of unripe Rubus coreanus Miq. and Dendropanax morbiferus H. Lév. extracts on rat aortic rings

Fig. 2

Effect of L-NAME and ODQ on rat thoracic aorta relaxation induced by 0.3 μg/mL (a) and 1 μg/mL (b) DP, Hy-DP and 5-uRCK. L-NAME, ODQ and a mixture of both (10 μΜ each) were superfused continuously over the strips. (c) Vasorelaxant effects of DP, Hy-DP and 5-uRCK in thoracic aortas with denuded endothelia (−E) and intact endothelia (+E). The relaxation (%) values (mean ± SEM) are relative to the basal (submaximal) relaxation levels measured before PHE treatment, which were taken to be 100%. NSP > 0.05, *P < 0.05, **P < 0.01 and ***P < 0.001 vs DP-only-treated aortae; ##P < 0.01, ###P < 0.001 vs Hy-DP-only-treated aortae; $$$P < 0.001 vs L-arginine-only-treated aortae; and &&&P < 0.001 vs 5-uRCK-only-treated aortae. (d) Inhibition of the vasorelaxant effects of DP, Hy-DP and 5-uRCK in endothelium-free thoracic aortae precontracted with 10 μM PHE. (e) Dose-dependent relaxation (%) induced by 5-uRCK in strips of isolated rat thoracic aortic rings with intact endothelia (+E) and denuded endothelia (−E)

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