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Table 4 Cytotoxicity and protein kinase inhibition of DSL-EA and DIL-EA extracts

From: Preclinical anticancer studies on the ethyl acetate leaf extracts of Datura stramonium and Datura inoxia

Samples Brine shrimp cytotoxicity Protein kinase inhibition Cytotoxicity
PC-3 MDA-MB 231 MCF-7 Normal lymphocytes
% Mortality 200 μg/ml LC50 μg/ml Diameter at 100 μg/disc MIC μg/disc % inhibition 20 μg/ml IC50 μg/ml % Inhibition 20 μg/ml IC50 μg/ml % Inhibition 20 μg/ml IC50 μg/ml % Inhibition 20 μg/ml IC50 μg/ml
Clear zone Bald zone
DSL-EA 96.96 ± 5.25a 12.04 ± 0.21 7.5 ± 0.58 12.50 ± 0.58c 100 14.4 ± 0.4b 38.03 ± 0.38b 40.2 ± 0.3b 4 ± 0.35c
DIL-EA 100 ± 0.00a 10.37 ± 0.56 9.00 ± 1 19.00 ± 0.58b 25 99.93 ± 0.11a 2.86 ± 0.1 98.64 ± 0.33a 1.56 ± 0.16 99.36 ± 0.72a 2.45 ± 0.04 23 ± 1.45b
Vincristine 79 ± 2.55a 6.89 ± 0.19
Doxorubicin 100 ± 0.00a 5.74 ± 0.18 99.43 ± 0.15a 2.95 ± 0.11 98.11 ± 0.48a 2.45 ± 0.24 98.62 ± 0.42a 3.2 ± 0.11
Surfactin 26.50 ± 1.0a
DMSO
  1. Values are presented as mean ± SD of triplicate analysis. Results of standards and/or controls are given in respective columns. Means with different superscripts (a-c) represent significantly different values at p < 0.05