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Fig. 3 | BMC Complementary Medicine and Therapies

Fig. 3

From: Modified Pulsatillae decoction inhibits DSS-induced ulcerative colitis in vitro and in vivo via IL-6/STAT3 pathway

Fig. 3

High-throughput transcriptomic sequencing of negative control group, model group and modified PD group (n = 3 in every group)

(A) The MA plot and volcano plot were used for showing variance in gene expression with respect to fold change (FC) and significance (p-value). Each dot represents an individual gene: The red point in the plot represented significantly upregulated or downregulated RNA (fold change> 2, P < 0.05) and the black point demonstrated RNA with no statistical differences (fold change< 2, P > 0.05) (Left: negative control group vs. model group; Middle: model group vs. modified PD group; Right: negative control group vs. modified PD group). (B) Microarray heat map demonstrates clustering of colon tissues (Left: negative control group vs. model group; Middle: model group vs. modified PD group; Right: negative control group vs. modified PD group). (C) GO classification of target genes. The 30 most significantly enriched GO terms for colon tissues between model group and modified PD group. (D) KEGG pathway classification of target genes. The Y-axis showed the name of pathway and the X-axis represented the rich factor. The point size indicated the number of differentially expressed genes in one pathway, and the color of the point corresponded to the range of the Q value. The 20 most significant up-regulated pathways (model group vs. modified PD group).

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