Effectiveness and cerebral responses of multi-points acupuncture for primary insomnia: a preliminary randomized clinical trial and fMRI study

Table 10 The different altered fALFF regions of different groups after acupuncture treatment

Group	Brain regions	BA	Side	Cluster size	MNI			t-value
Group	Brain regions	BA	Side	Cluster size	X	Y	Z	t-value
S vs N	Anterior Cingulate	25	R	51	3	18	−9	−5.12
	Insula		L	168	−15	30	15	−6.93
	Cerebellum Posterior Lobe		L	84	−15	−57	−57	4.51
	Brainstem		R	38	6	−24	−39	4.56
S vs M	Parahippocampa Gyrus		L	35	−27	− 36	−15	−5.18
	Superior Temporal Gyrus Middle Temporal Gyrus	22	L	348	−57	−18	−3	− 5.83
	Superior Temporal Gyrus		R	31	45	−39	9	−5.02
	Lentiform Nucleus		R	91	18	9	0	−4.92
	Middle Frontal Gyrus		L	37	−30	42	18	−5.09
	Middle Frontal Gyrus		L	33	−36	15	42	−4.69
	Middle Frontal Gyrus	6	L	50	−27	0	66	−4.66
	Precentral Gyrus		L	126	−51	0	12	−5.40
	Inferior Frontal Gyrus		L	126	−51	0	12	−5.40
	Inferior Frontal Gyrus	9	L	46	−48	3	27	−5.58
	Postcentral Gyrus	40	L	152	−48	−27	39	−4.61
	Inferior Parietal Lobule	40	L	152	−48	−27	39	−4.61
	Superior Parietal Lobule	7	L	55	−33	−69	48	−5.09
	Anterior Cingulate		L	62	−24	27	24	−5.32
	Supramarginal Gyrus	40	L	110	−54	−48	36	−5.73
	Angular Gyrus	40	L	110	−54	−48	36	−5.73
	Precuneus	39	R	33	36	−69	42	−4.59

The anatomical locations, approximate Brodmann areas (BA) and MNI coordinates that corresponded to the t-values of the representative peaks within each cluster were reported. S vs N S-Acu group vs N-Acu group. A positive t-value means that the increased fALFF in this brain region of S-Acu group was higher than that of N-Acu group. S vs M S-Acu group vs M-Acu group. A negative t-value means that the increased fALFF in this brain region of S-Acu group was lower than that of M-Acu group. All regions reached a voxel-level significance threshold of P < 0.005, FWE correct P = 0.05, cluster size> 30

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