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Table 2 eHealth technology characteristics (n = 69)

From: eHealth technologies assisting in identifying potential adverse interactions with complementary and alternative medicine (CAM) or standalone CAM adverse events or side effects: a scoping review

Name of eHealth Technology

Source Eligible Article(s) Included in Review

URL of eHealth Technology?

Type of eHealth Technology

Format

Year Established

Still in Existence?

Used Outside of the Authors’ Study?

Available for Anyone to Use?

Developer of eHealth Technology

Type of Developer

Purpose of eHealth Technology

Intended User(s) of eHealth Technology

Adverse Drug/Event Alerting, Reporting and/or Signal Detection Systems (n = 11)

Center for Food Safety and Applied Nutrition

Jackson et al. 2001 [25]

https://www.fda.gov/about-fda/office-foods-and-veterinary-medicine/center-food-safety-and-applied-nutrition-cfsan

Adverse event reporting tool and safety alerts

Website

1984

Yes

Yes

Yes, entirely free

U.S. Food and Drug Administration

Government

Website containing safety alert publications, guide documents and a reporting tool for dietary supplement adverse events

Healthcare providers, researchers, patients/public

Guangdong Quantitative Signal Detection System (GDQSDS)

Li et al. 2009 [26]; Zhang 2018 [27]

No

Adverse drug reaction signal detection and spontaneous reporting system

Web-based

Unclear

Unclear

Yes

Unclear

Authors

Researchers (authors)

“A web-based system comprising three software modules that prepare data, detect associations, and generate reports, was developed based on the Guangdong ADR monitoring platform” p. 730

Researchers

Institute for Safe Medication Practices (ISMP)

Motl et al. 2004 [28]

https://www.ismp.org

Adverse event reporting system

Website

1995 (website)

Yes

Yes

Yes, entirely free

The Institute for Safe Medication Practices (ISMP)

Not-for-Profit

Contains a medication error reporting program, and publishes newsletters, reports and safety alerts based on information received

Healthcare providers, patients/public

INVDOCK

Chen et al. 2002 [29]; Chen et al. 2006 [30]

Unclear

Adverse drug reaction signal detection

Software

2001

Yes

Yes

Unclear

Chen & Zhi (2001). See: https://doi.org/10.1002/1097-0134(20010501)43:2%3C217::AID-PROT1032%3E3.0.CO;2-G

Researchers

Software that allows for “computer-aided identification of potential protein targets of a small molecule” (Chen & Zhi 2001, p. 225 [85])

Researchers

Korea Institute of Drug Safety and Risk Management Korea Adverse Event Reporting System database (KIDS-KD)

Woo et al. 2019 [31]

Unclear

Adverse event reporting system and database

Unclear

2012

Unclear

Yes

Unclear

Korean Institute of Drug Safety & Risk Management (KIDS)

Researchers/Government

An adverse drug reaction reporting system

Healthcare providers

MedWatch

Jackson et al. 2001 [25]; Kiefer et al. 2001 [32]; Meyer et al. 2004 [33]; Motl et al. 2004 [28]

https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program/medical-product-safety-information

Adverse event reporting tool and safety reports

Website

Unclear

Yes

Yes

Yes, entirely free

U.S. Food and Drug Administration

Government

Safety alerts on drugs, natural products and other medical products

Healthcare providers, researchers, patients/public

National Coordination Centre, Pharmacovigilance Programme of India (NCC-PvPI) Database

Zhang 2018 [27]

No

Adverse drug reaction reporting system

Unclear

2010

Yes

Yes

Unclear

Government of India

Government

To conduct traditional medicines surveillance though a drug adverse event reporting system which reports to Vigibase

Healthcare providers, researchers, health organizations, patients/public

Shanghai Adverse Drug Reaction Spontaneous Reporting System (ADR-SRS)

Ye et al. 2009 [34]

Unclear

Adverse drug reaction detection/spontaneous reporting system and database

Unclear

2001

Yes

Yes

Unclear

National Adverse Drug Reaction Monitoring Center of China

Government

Web-based ADR detection system and reporting tool for TCM and chemical medicine

Healthcare providers, pharmaceutical manufacturers, researchers

Shanghai Drug Monitoring and Evaluative System (SDMES)

Ye et al. 2009 [34]; Zhang 2018 [27]

Unclear

Adverse drug reaction surveillance system

Unclear

2001

Unclear

Yes

Unclear

Shanghai Center for Adverse Drug Reaction Monitoring

Government

To locally monitor marketed drugs (including herbs) by working in partnership with ten hospitals in Shanghai that permit direct access to patient adverse drug reaction information

Researchers

Special Nutritionals Adverse Event Monitoring System

Jackson et al. 2001 [25]

Unclear

Adverse event reporting system

Web-based

Unclear

Unclear

Yes

Yes, entirely free

U.S. Food and Drug Administration

Government

Collects adverse event reports on dietary supplements, infant formulas, and medical foods from a variety of sources

Healthcare providers, researchers, patients/public

Unnamed

Archer et al. 2014 [35]

No

Adverse drug reaction alerting system

Unclear

Unclear

Unclear

Unclear

Unclear

Authors

Researchers (authors)

To automatically detect herb-drug interactions and classify their severity

Healthcare providers, researchers

Yellow Card Scheme

Ye et al. 2009 [34]

https://yellowcard.mhra.gov.uk/

Adverse event reporting system

Website

Unclear

Yes

Yes

Yes, entirely free

Medicines and Healthcare Products Regulatory Agency

Researchers/Government

A reporting tool that monitors the safety of healthcare products, including herbal products, in the UK

Healthcare providers (including pharmacists), patients/public

Databases (n = 34)

ABDAMED

Ogultarhan et al. 2016 [36]

https://abdata.de/datenangebot/abdamed/

Database

Website

Unclear

Yes

Yes

Unclear

ABDATA Pharma Data Service

Company

“ABDAMED is a commercial pharmaceutical database, which contains approved drug-related data, such as active ingredients, excipients, risks, indications, contraindications and adverse effects” (Ogultarhan et al. 2016, p. 169 [36])

Healthcare providers, researchers, patients

Alticopeia Herbal Medicine Database

Clauson et al. 2008 [37]; Fischer et al. 2005 [44]

http://www.ddhsoftware.com/gallery.html?show=number&record=527

Database

Mobile app

2001

Yes

Yes

Yes, entirely free

DDH Software

Company

“To facilitate understanding of herbal medicine by physicians and other ‘traditional’ health care workers.” (See: http://www.ddhsoftware.com/gallery.html?show=number&record=527)

Healthcare providers

ALTMEDA

Ogultarhan et al. 2016 [36]

Unclear

Database

Unclear

2016

Unclear

Unclear

Unclear

Authors

Researchers (authors)

A database that includes complementary and drug-related data (Ogultarhan et al. 2016, p. 167 [36])

Healthcare providers, researchers

American Botanical Council

Fitzpatrick 2010 [38]; Jackson et al. 2001 [25]; Kiefer et al. 2001 [32]; Motl et al. 2004 [28]

http://abc.herbalgram.org/site/PageServer

Database

Website

1988

Yes

Yes

Yes, partially without subscription

American Botanical Council

Council

A nonprofit, research and education organization, providing access to several databases (i.e. HerbMedPro, the Complete German Commission E Monographs) among other herbal resources (See: www.herbalgram.org)

Healthcare providers, researchers, patients/public

Caremark Drug Interactions

Yap et al. 2012 [39]

http://cpref.goldstandard.com/inter.asp?r=8084

Database

Website

Unclear

Yes

Yes

Yes, entirely free

Gold standard Inc.

Company

A tool for checking drug, herb and vitamin interactions

Patients/public

China Natural Products Database (CNPD)

Lee et al. 2015 [40]

Unclear

Database

Unclear

Unclear

Unclear

Unclear

Unclear

No information

Unclear

No information available

Researchers

Chinese Ethnic Minority Traditional Drug Database (CEMTDD)

Xie et al. 2015 [41]

http://www.cemtdd.com/ (inaccessible)

Database

Website

2015

Unclear

Yes

Unclear

Jinhui Wang

Researchers

A database containing Chinese minority herbs, built on data retrieved from various resources (mainly from Kazakh and Uygur traditional drugs) containing a variety of modules p. 399

Healthcare providers, researchers

Clinical Pharmacology (also known as Gold Standard)

Gregory et al. 2016 [42]

https://www.clinicalpharmacology.com/

Database

Website

Unclear

Yes

Yes

Yes, but only with a subscription

Elsevier

Company

Monographs, reports, guides, resources and drug information of prescription drugs and herbal/nutritional products

Healthcare providers, researchers

Danish National Drug Interaction Database

Olesen et al. 2013 [43]

http://www.interaktionsdatabasen.dk/

Database

Website

2003

Yes

Yes

Yes, entirely free

Danish Medicines Agency

Government

“The Danish Drug Interaction database is an electronic search tool for searching and learning about the effects of and adverse reactions from taking two or more different kinds of medication” (See: https://www.danishhealthdata.com/find-health-data/Interaktionsdatabasen)

Healthcare providers

DoubleCheckMD

Yap et al. 2012 [39]

Unclear

Database

Unclear

Unclear

No

Yes

Unclear

Enhanced Medical Decisions Inc.

Company

Tool for users to check for drug interactions and side effects

Healthcare providers, patients/public

DrDrugs

Clauson et al. 2008 [37]; Fischer et al. 2005 [44]

https://www.skyscape.com/product/drdrugs-drug-guide-for-physicians

Database

Website and mobile app

Unclear

Yes

Yes

Yes, but only with a subscription

Skyscape

Company

Drug information, dosing calculators, monographs, safety alerts

Healthcare providers

Drug Information (formerly DrugDigest)

Motl et al. 2004 [28]

https://www.express-scripts.com/medco/consumer/ehealth/druginfo/dlmain.jsp?WC=N

Database

Website

Unclear

Yes

Yes

Yes, entirely free

Express Scripts Inc

Company

To provide consumers with information on drugs and CAM supplements, including adverse effects

Patients/public

Drug Product Database

Motl et al. 2004 [28]

https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html

Database

Website

Unclear

Yes

Yes

Yes, entirely free

Health Canada

Government

Search tool for drugs and certain natural health products in Canada containing monographs

Healthcare providers, patients/public

Drugbank

Kim et al. 2019 [45]; Lee et al. 2015 [40]; Spanakis et al. 2019 [46]

https://www.drugbank.ca/

Database

Website

2006

Yes

Yes

Yes, entirely free

Wishart Research Group

Researchers

A bioinformatics and cheminformatics resource that combines detailed drug data with comprehensive drug target information

Healthcare providers, researchers, patients/public

Encyclopedia of Traditional Chinese Medicine (ETCM)

Xu et al. 2019 [47]

http://www.nrc.ac.cn:9090/ETCM/

Database

Website

Unclear

Yes

Yes

Yes, entirely free

Authors

Researchers (authors)

Contains information and data on traditional Chinese medicine herbal drugs, formulas, predicted drug targets and diseases

Healthcare providers, researchers

Epocrates Rx (plus or pro)

Clauson et al. 2008 [37]; Fischer et al. 2005 [44]; Yap et al. 2012 [39]

https://online.epocrates.com/

Database

Website and mobile app

Unclear

Yes

Yes

Yes, but only with a subscription

Athenahealth

Company

Provides monographs, a drug interaction checker, pill identifier, dosing calculators, and formularies

Healthcare providers

Guide to Popular Natural Products

Clauson et al. 2008 [37]; Fischer et al. 2005 [44]

http://www.skyscape.com/EStore/ProductDetail.aspx?ProductID=951 (inaccessible)

Database

Mobile app

Unclear

No

Yes

Unclear

Skyscape

Company

No information available

Unclear

IBIS: Integrative BodyMind Information System

Allais et al. 2000 [65]; Kiefer et al. 2001 [32]; Wootton 1997 [48]

http://www.ouribis.com/

Database

Software

1992

Yes

Yes

Yes, but only with a subscription

Medicineworks

Company

Provides clinical reference database with drug-herb and drug-nutrient interactions, among other information about nutritional supplements and botanical preparations

Healthcare providers, researchers

International Drug Information System (INTDIS)

Fucik et al. 2002 [49]

No

Database

Unclear

1978

No (has been replaced by Vigibase)

Yes

No

World Health Organization International Drug Monitoring Program

Government

To collect and store information on herbal medicines, allopathic drugs and adverse drug reactions from various countries

National centers (i.e. World Health Organization), researchers, pharmaceutical companies

Lexi-Natural (includes LexiComp)

Clauson et al. 2008 [37]; Gregory et al. 2016 [42]; Fischer et al. 2005 [44]; Motl et al. 2004 [28]; Yap et al. 2012 [39]

http://webstore.lexi.com/Store/Individual-Databases/Lexi-Natural-Products

Database

Website and mobile app

Unclear

Yes

Yes

Yes, but only with a subscription

Wolters Kluwer

Company

Provides information on natural products, including interactions, adverse reactions, toxicology, etc. and includes monographs

Healthcare providers (including pharmacists, physicians, nurses, dentists), researchers

MedicinesComplete (includes Herbal Medicines; formerly known as the British National Formulary)

Jackson 2001 [50]; Jackson et al. 2001 [25]; Yap et al. 2012 [39]

https://about.medicinescomplete.com/publication/herbal-medicines/

Database

Website

Unclear

Yes

Yes

Yes, but only with a subscription

Pharmaceutical Press Editorial, The Royal Pharmaceutical Society

Company

Resources on herbal medicines including “uses, dosage, evidence of efficacy, adverse effects, contraindications, use in pregnancy and lactation, drug interactions” (See: https://www.pharmpress.com/product/MC_HERB/herbal-medicines)

Healthcare providers (including pharmacists)

Micromedex (includes DrugDex, Drug-Reax, AltMedDex)

Clauson et al. 2008 [37]; Fischer et al. 2005 [44]; Jackson 2001 [50]; Jackson et al. 2001 [25]; Kiefer 2001 [32]; Meyer et al. 2004 [33]; Walker 2002 [51]; Yap et al. 2012 [39]

https://www.micromedexsolutions.com/home/dispatch/ssl/true

Database

Website and mobile app

mid-1970s

Yes

Yes

Yes, but only with a subscription

IBM

Company

Contains evidence-based documents on prescription and non-prescription drugs; contains information such as dosing, adverse effects, interactions, warnings and efficacy

Healthcare providers, researchers

Natural Medicines (formerly Natural Medicine Comprehensive Database (NMCD) and Natural Standard Database (NSD))

Archer et al. 2014 [35]; Boddy et al. 2011 [52]; Boehmer et al. 2011 [53]; Clauson et al. 2008 [37]; Faubert et al. 2010 [54]; Fischer et al. 2005 [44]; Fitzpatrick 2010 [38]; Gregory et al. 2016 [42]; Jackson et al. 2001 [25]; Kiefer et al. 2001 [32]; Motl et al. 2004 [28]; Sun et al. 2019 [55]; Sweet al al. 2003 [56]; Tomasulo 2003 [57]; Walker 2002 [51]; Yap et al. 2012 [39]

https://naturalmedicines.therapeuticresearch.com/

Database

Website and mobile app

early 2000s

Yes

Yes

Yes, but only with a subscription

Therapeutic Research Center

Company

Contains information about herbs and dietary supplements, including 15 categories of information which address the most common questions faced by practitioners; also provides interactive tools for safety, effectiveness and interactions

Healthcare providers, researchers, patients

OncoRx Database (called Onco-Rx as a website, and OncoRx-MI as a mobile app)

Yap et al. 2012 [39]

http://www.onco-informatics.com/oncorx/

Database

Website and mobile app

2007 (website), unclear (mobile app)

Yes

Yes

Yes, but only with a subscription

Dr. Kevin Yap Research Group

Researchers

Detects drug-CAM interactions (DCIs) and provides information on “interaction effects, severities, mechanisms of interactions, substantiating evidences and references, as well as overall management plans for the chemotherapy regimens” (Yap et al. 2012, p. 167 [39])

Healthcare providers, researchers, patients/public

PEPID Drug Information Database

Clauson et al. 2008 [37]; Fischer et al. 2005 [44]

https://www.pepid.com/

Database

Website and mobile app

Unclear

Yes

Yes

Yes, but only with a subscription

PEPID

Company

Clinical decision suites for a variety of healthcare providers, providing information on drugs, herbal medicines and supplements, and an Interaction checker and toxicology resources

Healthcare providers

PharmDB-K

Lee et al. 2015 [40]

http://pharmdb-k.org/

Database

Website

Unclear

Yes

Yes

Yes, entirely free

Authors, Information Center for Bio-pharmacological Network (i-Pharm)

Researchers (authors)

Provides comprehensive traditional Korean medicine-associated compound, drug, disease indication, and protein relationship information

Researchers

PharmGKB

Yap et al. 2012 [39]

https://www.pharmgkb.org/

Database

Website

2001

Yes

Yes

Yes, entirely free

Shriram Center for Bioengineering and Chemical Engineering

Researchers

A pharmacogenomics knowledge resource providing clinical information including clinical guidelines and drug labels, potentially clinically actionable gene-drug associations and genotype-phenotype relationships

Healthcare providers (including pharmacists), researchers

Tarascon Pocket Pharmacopoeia

Clauson et al. 2008 [37]; Fischer et al. 2005 [44]

https://www.tarascon.com/products/mobile/

Database

Mobile app

Unclear

Yes

Yes

Yes, but only with a subscription

Tarascon Publishing

Company

Contains drug information to help clinicians make better decisions at the point of care

Healthcare providers

TCM Assistant

Yap et al. 2012 [39]

http://www.tcmassistant.com/ (inaccessible)

Database

Website

2004

Unclear

Yes

Unclear

e-MS Inc

Company

Provides resources on traditional Chinese medicine herbs, including herbs name, their formulas, their usage in curing disease and patent description

Healthcare providers, researchers

TCM Database@Taiwan

Lee et al. 2015 [40]; Sun et al. 2019 [55]; Xie et al. 2015 [41]

http://tcm.cmu.edu.tw/ (inaccessible)

Database

Website

2011

Unclear

Yes

Unclear

Calvin Yu-Chian Chen

Researchers

A database for Chinese traditional medicinal compounds, providing freely downloadable 3D compound structures of ingredients used in traditional Chinese medicine

Researchers

TCMGeneDIT

Xu et al. 2019 [47]

http://tcm.lifescience.ntu.edu.tw/

(inaccessible)

Database

Website

Unclear

Unclear

Yes

Unclear

Fang et al. 2018 See: https://doi.org/10.1186/1472-6882-8-58

Researchers

A traditional Chinese medicine database that provides information about genes, diseases, effects and ingredients

Researchers

TCM-MESH

Xu et al. 2019 [47]

http://mesh.tcm.microbioinformatics.org/

Database

Website

Unclear

Yes

Yes

Yes, entirely free

Zhang et al. 2017 See: https://doi.org/10.1038/s41598-017-03039-7

Researchers

Database that contains TCM-related information on herbs, compounds, diseases and genes. Includes side-effects and has a search tool

Healthcare providers, researchers

Traditional Chinese Medicine Information Database (TCM-ID)

Chen et al. 2006 [30]; Lee et al. 2015 [40]; Xu et al. 2019 [47]

http://bidd.nus.edu.sg/group/TCMsite/

Database

Unclear

2005

Yes

Yes

Yes, entirely free

Authors

Researchers (authors)

Provides information about traditional Chinese medicines including prescriptions, constituent herbs, herbal ingredients, molecular structure and functional properties of active ingredients, therapeutic and side effects, and clinical indications

Healthcare providers, researchers

Vigibase (includes Vigilyze)

Ye et al. 2009 [34]; Zhang 2018 [27]

https://www.who-umc.org/vigibase/vigibase/

Database

Website

1971

Yes

Yes

Yes, but only with a subscription

WHO Uppsala Monitoring Center, World Health Organization

Government

A global pharmacovigilance database of individual case safety reports, with over 20 million reports of suspected adverse effects of medicines

Healthcare providers (including physicians, dentists, nurses, and pharmacists)

Factsheets/Healthcare Information (n = 13)

About Herbs

Boddy et al. 2008 [52]; Molassiotis et al. 2004 [58]; Yap et al. 2012 [39]

https://www.mskcc.org/cancer-care/diagnosis-treatment/symptom-management/integrative-medicine

Factsheets/healthcare information

Website and mobile app

Unclear

Yes

Yes

Yes, entirely free

Memorial Sloan-KetteringCancer Center

Researchers

Resources on herbs, botanicals and other CAM drugs. Includes information on CAM interactions

Healthcare providers, researchers, patients

ALMEKO

Ogultarhan et al. 2016 [36]

https://play.google.com/store/apps/details?id=de.icancode.almeko&hl=de

Factsheets/healthcare information

Mobile app

2016

Yes

Unclear

Unclear

Authors

Researchers (authors)

ALMEKO bundles information on different areas of complementary and alternative medicine, providing an indication check, and overview of potential therapies for the alleviation of symptoms (See: https://apkcombo.com/almeko/de.icancode.almeko/)

Healthcare providers, public

AlternativeDr.com

Motl et al. 2004 [28]

http://www.alternativedr.com

Factsheets/healthcare information

Unclear

Unclear

Unclear

Yes

Yes, entirely free

Advisory panel of MDs and experts in natural medicine

Practitioners

“Lists herbal interactions with several prescription and over the-counter medications” (Motl et al. 2004, p. 109 [28])

Healthcare providers, public

Complementary and Alternative Medicine

Boddy et al. 2008 [52]

https://www.cancer.gov/about-cancer/treatment/cam

Factsheets/healthcare information

Website

Unclear

Yes

Yes

Yes, entirely free

National Cancer Institute, National Institutes of Health

Government

Provides summaries on commonly used complementary and alternative medicines for patients and healthcare providers

Healthcare providers, patients/public

Dietary Supplement Fact Sheets

Motl et al. 2004 [28]

https://ods.od.nih.gov/factsheets/list-all/

Factsheets/healthcare information

Website

1998

Yes

Yes

Yes, entirely free

Office of Dietary Supplements, National Institute of Health

Government

Contains factsheets on supplements, vitamins and minerals

Healthcare providers, patients/public

Herb-Drug Interactions, NCCIH Clinical Digest

Allais et al. 2000 [65]; Boddy et al. 2008 [52]; Gregory et al. 2016 [42]; Jackson et al. 2001 [25]; Motl et al. 2004 [28]

https://nccih.nih.gov/health/providers/digest/herb-drug

Factsheets/healthcare information

Website

2015

Yes

Yes

Yes, entirely free

National Center for Complementary and Integrative Health (NCCIH) (formerly the National Center for Complementary and Alternative Medicine (NCCAM))

Government

Provides healthcare providers with information about several herbs and their potential interactions with other agents

Healthcare providers

Herbs at a Glance

Boddy et al. 2008 [52]; Jackson et al. 2001 [25]; Gregory et al. 2016 [42]; Motl et al. 2004 [28]

https://nccih.nih.gov/health/herbsataglance.htm

Factsheets/healthcare information

Website

Unclear

Yes

Yes

Yes, entirely free

National Center for Complementary and Integrative Health (NCCIH) (formerly the National Center for Complementary and Alternative Medicine (NCCAM))

Government

Provides basic information about specific herbs/botanicals, including common names, scientific evidence, potential side effects and cautions, and resources for more information

Healthcare providers, researchers, patients

KATIS (based off ALTMEDA)

Ogultarhan et al. 2016 [36]

http://www.komplementaeremedizin.de

Factsheets/healthcare information

Website

2016

Unclear

Unclear

Unclear

Authors

Researchers (authors)

A web-based information system for complementary medicine, designed to assist patients and health care professionals search for alternative therapies efficiently

Healthcare providers, patients

Medline Plus

Motl et al. 2004 [28]

https://medlineplus.gov/druginformation.html

Factsheets/healthcare information

Website

1998

Yes

Yes

Yes, entirely free

U.S. National Library of Medicine, National Institutes of Health

Government

Information resource on health, drugs and herbal supplements

Patients/public

Medscape

Motl et al. 2004 [28]; Spanakis et al. 2019 [46]

https://www.medscape.com/

Factsheets/healthcare information

Website and mobile app

1995

Yes

Yes

Yes, entirely free

WebMD (formerly SCP Communications Inc.)

Company

Provides clinical resources, news, and drug/disease information, as well as a drug interaction checker tool

Healthcare providers

PharmActa

Spanakis et al. 2019 [46]

No

Factsheets/healthcare information

Mobile app

Unclear

Unclear

Unclear

No

Authors

Researchers (authors)

An “app for personalized pharmaceutical care with information regarding drug-herbal medicinal products interactions” (Spanakis et al. 2019, p. 1 [46])

Patients

RxList (owned by WebMD)

Motl et al. 2004 [28]; Spanakis et al. 2019 [46]

https://www.rxlist.com/script/main/hp.asp

Factsheets/healthcare information

Website

1995

Yes

Yes

Yes, entirely free

WebMD (formerly a team of pharmacists)

Company

An online medical resource providing pharmaceutical information on brand and generic drugs and CAM, including an interaction checker and factsheets

Healthcare providers, patients/public

RxMed

Motl et al. 2004 [28]

https://www.rxmed.com

Factsheets/healthcare information

Website

1994

Yes

Yes

Yes, entirely free

RxMed Medical Advisory

Company

Provides illness and medication information, including CAM factsheets, as well as access to various medical products and services

Healthcare providers, patients

Search Engines (n = 4)

Drugs.com

Motl et al. 2004 [28]; Spanakis et al. 2019 [46]; Yap et al. 2012 [39]

https://www.drugs.com/

Search engine

Website and mobile app

2001

Yes

Yes

Yes, entirely free

Cerner Multum and Thomson Micromedex (and Wolters Kluwer)

Company

Contains information about prescriptions and CAM therapies, as well as an interaction checker tool

Healthcare providers, patients/public

Electronic Medicines Compendium (EMC)

Motl et al. 2004 [28]

https://www.medicines.org.uk/emc/

Search engine

Website

1999

Yes

Yes

Yes, entirely free

Datapharm Ltd.

Company

Provides information, including leaflets, on drugs (including CAM) in the UK, as well as an adverse effect reporting tool

Healthcare providers (specifically pharmacists), patients/public

European Medicines Agency (EMA)

Spanakis et al. 2019 [46]

https://www.ema.europa.eu/en

Search engine

Website

Unclear

Yes

Yes

Yes, entirely free

European Medicines Agency

Government

Search tool to find information on herbal drugs and provides drug profiles

Healthcare providers, researchers, patients/public

Merck Manual

Motl et al. 2004 [28]

https://www.merckmanuals.com/en-ca/

Search engine

Website

1999

Yes

Yes

Yes, entirely free

Merck & Co. Inc.

Company

A search tool that allows users to find information on drugs and supplements (including side effects and interactions)

Healthcare providers, patients/public

Other (n = 6)

Adverse Drug Reaction Information Bulletin (ADRIB)

Gao et al. 2015 [59]; Zhang 2018 [27]

http://www.sda.gov.cn/WS01/CL0078/ (inaccessible)

Bulletin

Website

2001

Unclear

Yes

Unclear

China Food and Drug Admininstration

Government

Technical bulletin that provides information on ADRs and potential hazardous drugs to highlight current pharmacovigilance concerns in China

Public

Cancer CAM™ Web-based continuing education program

Brink et al. 2004 [60]

http://www.nurse-ceus-stat.com/ (inaccessible)

Continuing education module

Web-based

2004

Unclear

Unclear

Unclear

HealthMark Multimedia

Company

To provide continuing education to nurses, allied health and health educators on the use of CAM for prostate cancer patients

Healthcare providers (including nurses and allied health professions), health/patient educators

Evaluation of Anthroposophical Medicine (EvaMed) Pharmacovigilance Network

Hamre et al. 2017 [61]; Tabali et al. 2012 [62]

No

Electronic Pharmacovigilance System

Unclear

2004

Unclear

Yes

No

Havelhoehe Research Institute

Researchers

Online adverse drug reaction reporting tool that connects with the hospital EMR system and integrates into the daily clinical practice of physicians

Healthcare providers, researchers

HIV Drug Interactions

Motl et al. 2004 [28]

https://www.hiv-druginteractions.org/checker

Interaction checker

Website

1999

Yes

Yes

Yes, entirely free

Liverpool HIV pharmacology group from the University of Liverpool

Researchers

Tool to check for interaction of HIV drugs and other drugs (includes complementary and alternative medicines)

Healthcare providers, researchers, patients

Ontology-based Artificial Neural Network Model for Drug Side-Effects

Yao et al. 2019 [63]

No

Model

Artificial Intelligence

2019

Unclear

Unclear

Unclear

Authors

Researchers (authors)

An ontology-based model for artificial intelligence-assisted medicine side-effect prediction

Healthcare providers, researchers

Herbopolis

Ee et al. 2018 [64]

https://play.google.com/store/apps/details?id=com.herbopolisgame.alpha&hl=en

Serious game

Mobile app

2017

Yes

Unclear

Yes, entirely free

Authors

Researchers (authors)

To motivate players to learn more about herbal medicine

Public