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Table 2 Top 30 key targets of DMSCO acting on AD (degree ≥ 50)

From: Uncovering the active compounds and effective mechanisms of the dried mature sarcocarp of Cornus officinalis Sieb. Et Zucc. For the treatment of Alzheimer’s disease through a network pharmacology approach

Targets

Official name

Degree

BC

CC

TP53

Tumor protein p53

102

0.082

0.557

MAPK1

Mitogen-activated protein kinase 1

95

0.037

0.539

AKT1

AKT serine/threonine kinase 1

93

0.029

0.533

VEGFA

Vascular endothelial growth factor A

90

0.033

0.538

INS

Insulin

86

0.087

0.547

IL6

Interleukin 6

86

0.047

0.54

STAT3

Signal transducer and activator of transcription 3

85

0.017

0.519

PIK3CA

Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha

84

0.037

0.519

MAPK8

Mitogen-activated protein kinase 8

83

0.029

0.529

MAPK3

Mitogen-activated protein kinase 3

83

0.027

0.532

SRC

SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase

81

0.027

0.513

APP

Amyloid beta precursor protein

77

0.072

0.514

JUN

Jun proto-oncogene, AP-1 transcription factor subunit

77

0.028

0.532

EGFR

Epidermal growth factor receptor

74

0.027

0.518

HRAS

HRas Proto-Oncogene, GTPase

70

0.014

0.503

IGF1

Insulin like growth factor 1

70

0.013

0.511

CTNNB1

Catenin beta 1

66

0.033

0.498

TNF

Tumor necrosis factor

66

0.011

0.505

MYC

MYC proto-oncogene, bHLH transcription factor

62

0.012

0.498

MMP9

Matrix metallopeptidase 9

59

0.024

0.498

FGF2

Fibroblast growth factor 2

58

0.01

0.495

FOS

Fos proto-oncogene, AP-1 transcription factor subunit

54

0.015

0.498

CASP3

Caspase 3

54

0.011

0.492

CCND1

Cyclin D1

54

0.004

0.475

PTEN

Phosphatase and tensin homolog

53

0.005

0.474

RELA

RELA proto-oncogene, NF-kB subunit

52

0.007

0.487

HGF

Hepatocyte growth factor

51

0.006

0.484

BDNF

Brain derived neurotrophic factor

50

0.021

0.498

CDH1

Cadherin 1

50

0.013

0.487

  1. BC Betweenness centrality, CC Closeness centrality