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Fig. 3 | BMC Complementary Medicine and Therapies

Fig. 3

From: Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NFκB signaling

Fig. 3

Pao extract regulated the pro-apoptotic and inflammation-associated genes in BPH-1 and WPMY-1 cells. a Downstream target genes of Pao extract detected by gene expression profiling analysis. BPH-1 and WPMY-1 cells were treated with Pao extract (250 μg/ml) or vehicle for 48 h. Heatmap of differentially expressed genes under the treatment of Pao extract by microarray (1.4-fold as the cutoff), compared with vehicle-treatment. Rows corresponded to genes and were ordered by hierarchical clustering. The values used for clustering were the expression levels normalized to average of all samples. b Heatmap of the pro-apoptotic and inflammation-associated genes from panel a. c The mRNA expression levels of pro-apoptotic and inflammation-associated genes (PDCD4, DDIT3 and FBXO32) in BPH-1 and WPMY-1 cells by qRT-PCR. d The protein expression levels of pro-apoptotic and inflammation-associated genes (PDCD4 and DDIT3) in BPH-1 and WPMY-1 cells by Western blotting. * p < 0.05, ** p < 0.01, and *** p < 0.001

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