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Table 3 Systolic blood pressure, diastolic blood pressure and mean arterial pressure in sham rats fed a control diet and OVX rats fed a HFFD (OHFFD) that received 20-hydroxyecdysone (20E) or pioglitazone (PIO)

From: 20-Hydroxyecdysone ameliorates metabolic and cardiovascular dysfunction in high-fat-high-fructose-fed ovariectomized rats

 

SHAM

OHFFD

OHFFD + 20E (5 mg/kg Bw)

OHFFD + 20E (10 mg/kg Bw)

OHFFD + 20E (20 mg/kg Bw)

OHFFD + PIO (10 mg/kg Bw)

SBP, mmHg

 Baseline

119.7 ± 2.4

125.9 ± 1.8

123.7 ± 1.0

122.9 ± 1.6

126.9 ± 1.3

119.9 ± 1.4

 Week 12

119.7 ± 1.3

153.4 ± 3.1#

136.6 ± 2.8*

128.7 ± 3.0*

129.1 ± 2.7*

130.8 ± 5.1*

DBP, mmHg

 Baseline

87.8 ± 4.1

92.2 ± 4.1

92.7 ± 1.3

94.5 ± 2.3

96.8 ± 1.7

86.2 ± 1.7

 Week 12

86.1 ± 3.8

114.6 ± 2.8#

108.5 ± 2.8*

99.7 ± 2.5*

98.7 ± 3.8*

98.2 ± 5.9*

MAP, mmHg

 Baseline

98.5 ± 3.6

100.6 ± 2.6

104.9 ± 1.7

104.3 ± 1.7

106.5 ± 1.5

98.4 ± 1.1

 Week 12

96.9 ± 2.8

126.9 ± 2.6#

115.3 ± 3.8*

109.1 ± 2.6*

107.1 ± 3*

108.6 ± 3.1*

  1. Values are means ± SEMs for 7–8 animals/group
  2. Data for comparisons between groups were analyzed using one-way ANOVA followed by Tukey’s post hoc analysis. #P < 0.05 vs. sham; *P < 0.05 vs. OHFFD