| SHAM | OHFFD | OHFFD + 20E (5 mg/kg Bw) | OHFFD + 20E (10 mg/kg Bw) | OHFFD + 20E (20 mg/kg Bw) | OHFFD + PIO (10 mg/kg Bw) |
---|---|---|---|---|---|---|
SBP, mmHg | ||||||
 Baseline | 119.7 ± 2.4 | 125.9 ± 1.8 | 123.7 ± 1.0 | 122.9 ± 1.6 | 126.9 ± 1.3 | 119.9 ± 1.4 |
 Week 12 | 119.7 ± 1.3 | 153.4 ± 3.1# | 136.6 ± 2.8* | 128.7 ± 3.0* | 129.1 ± 2.7* | 130.8 ± 5.1* |
DBP, mmHg | ||||||
 Baseline | 87.8 ± 4.1 | 92.2 ± 4.1 | 92.7 ± 1.3 | 94.5 ± 2.3 | 96.8 ± 1.7 | 86.2 ± 1.7 |
 Week 12 | 86.1 ± 3.8 | 114.6 ± 2.8# | 108.5 ± 2.8* | 99.7 ± 2.5* | 98.7 ± 3.8* | 98.2 ± 5.9* |
MAP, mmHg | ||||||
 Baseline | 98.5 ± 3.6 | 100.6 ± 2.6 | 104.9 ± 1.7 | 104.3 ± 1.7 | 106.5 ± 1.5 | 98.4 ± 1.1 |
 Week 12 | 96.9 ± 2.8 | 126.9 ± 2.6# | 115.3 ± 3.8* | 109.1 ± 2.6* | 107.1 ± 3* | 108.6 ± 3.1* |