Fig. 6

Effect of diosgenin on the Nrf2/ HO-1 signaling pathway. a Immunoblot analyses of the protein levels of Nrf2, HO-1 and NQO1 in sciatic nerves treated with diosgenin 50 mg/kg or 100 mg/kg. b-d Administration of diosgenin increased the protein levels of Nrf2 in diabetic mice, and also increased the levels of HO-1 and NQO1. All data are presented as mean ± S.E.M. (n = 3). ^*p < 0.05, ^**p < 0.01