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Table 2 Common targets between PRA and IDA

From: Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy

NO.Protein IDGene nameProtein nameProtein Class
1P31645SLC6A4solute carrier family 6 member 4transporter
2Q01959SLC6A3solute carrier family 6 member 3transporter
3P23975SLC6A2solute carrier family 6 member 2transporter
4P33527ABCC1ATP binding cassette subfamily C member 1transporter
5P19793RXRAretinoid X receptor alphanucleic acid binding; receptor; transcription factor
6P03372ESR1estrogen receptor 1nucleic acid binding; receptor; transcription factor
7P05412JUNJun proto-oncogene, AP-1 transcription factor subunitnucleic acid binding; transcription factor
8P10275ARandrogen receptornucleic acid binding; receptor; transcription factor
9P37231PPARGperoxisome proliferator activated receptor gammanucleic acid binding; receptor; transcription factor
10P27338MAOBmonoamine oxidase Bnucleic acid binding; oxidoreductase; transferase
11P55055NR1H2nuclear receptor subfamily 1 group H member 2nucleic acid binding; receptor;transcription factor
12O75469NR1I2nuclear receptor subfamily 1 group I member 2nucleic acid binding; receptor; transcription factor
13P06746POLBDNA polymerase betanucleic acid binding
14O95342ABCB11ATP binding cassette subfamily B member 11hydrolase; protease
15Q2M3G0ABCB5ATP binding cassettesubfamily B member 5hydrolase; protease
16P22303ACHEAcetylcholinesterasehydrolase; protease
17P03956MMP1matrix metallopeptidase 1hydrolase; protease
18P00734F2coagulation factor II, thrombinhydrolase; protease
19P08253MMP2matrix metallopeptidase 2hydrolase; protease
20P08183ABCB1ATP binding cassette subfamily B member 1hydrolase; protease
21P08709F7coagulation factor VIIhydrolase; protease
22P45983MAPK8mitogen-activated protein kinase 8kinase; transferase
23Q13315ATMATM serine/threonine kinasekinase;nucleic acid binding; transferase
24P06493CDK1cyclin dependent kinase 1kinase; transferase
25P48736PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammakinase; transferase
26P47989XDHxanthine dehydrogenaseoxidoreductase
27P04040CATcatalaseoxidoreductase
28P09917ALOX5arachidonate 5-lipoxygenaseoxidoreductase
29P08684CYP3A4cytochrome P450 family 3 subfamily A member 4oxidoreductase
30P16050ALOX15arachidonate 15-lipoxygenaseoxidoreductase
31P23219PTGS1prostaglandin-endoperoxide synthase 1oxidoreductase
32P05177CYP1A2cytochrome P450 family 1 subfamily A member 2oxidoreductase
33P35354PTGS2prostaglandin-endoperoxide synthase 2oxidoreductase
34Q16850CYP51A1cytochrome P450 family 51 subfamily A member 1oxidoreductase
35P09601HMOX1heme oxygenase 1oxidoreductase
36P18054ALOX12arachidonate 12-lipoxygenase, 12S typeoxidoreductase
37P14550AKR1A1aldo-keto reductase family 1 member A1oxidoreductase
38O60218AKR1B10aldo-keto reductase family 1 member B10oxidoreductase
39P04141CSF2colony stimulating factor 2signaling molecule
40P10415BCL2BCL2, apoptosis regulatorsignaling molecule
41P01375TNFtumor necrosis factosignaling molecule
42P27487DPP4dipeptidyl peptidase 4enzyme modulator; hydrolase; protease
43P05121SERPINE1serpin family E member 1enzyme modulator
44P42574CASP3caspase 3enzyme modulator; hydrolase; protease
45P07550ADRB2adrenoceptor beta 2receptor
46P25105PTAFRplatelet activating factor receptorreceptor
47P08238HSP90AB1heat shock protein 90 alpha family class B member 1chaperone
48P04637TP53tumor protein p53transcription factor
49P17931LGALS3galectin 3cell adhesion molecule; signaling molecule
50P05231IL6interleukin 6None
51P00918CA2carbonic anhydrase 2None
52P00915CA1carbonic anhydrase 1None
53P01130LDLRlow density lipoprotein receptorNone
54P11388TOP2ADNA topoisomerase II alphaNone
55P35503UGT1A3UDP glucuronosyltransferase family 1 member A3None
56O60656UGT1A9UDP glucuronosyltransferase family 1 member A9None
57P04035HMGCR3-hydroxy-3-methylglutaryl -CoA reductaseNone
58P10636MAPTmicrotubule associated protein tauNone
59P26358DNMT1DNA methyltransferase 1None
60P35228NOS2nitric oxide synthase 2None
61P05093CYP17A1Cytochrome P450 family 17 subfamily A member 1None
62P16581SELEselectin ENone
63P04114APOBapolipoprotein BNone
64P17612PRKACAprotein kinase cAMP-activated catalytic subunit alphaNone
65O00255MEN1menin 1None
66P08700IL3interleukin 3None
67P19320VCAM1vascular cell adhesion molecule 1None
68Q9HAW9UGT1A8UDP glucuronosyl transferase family 1member A8None
69P29474NOS3nitric oxide synthase 3None
70Q16790CA9carbonic anhydrase 9None
71P83111LACTBlactamase betaNone
72P06276BCHEbutyrylcholinesteraseNone
73P09211GSTP1glutathione S-transferase pi 1None
74P06213INSRinsulin receptorNone
75P14679TYRtyrosinaseNone
76Q12809KCNH2potassium voltage-gated channel subfamily H member 2None
77P27169PON1paraoxonase 1None