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Table 2 Common targets between PRA and IDA

From: Uncovering the mechanism of the effects of Paeoniae Radix Alba on iron-deficiency anaemia through a network pharmacology-based strategy

NO.

Protein ID

Gene name

Protein name

Protein Class

1

P31645

SLC6A4

solute carrier family 6 member 4

transporter

2

Q01959

SLC6A3

solute carrier family 6 member 3

transporter

3

P23975

SLC6A2

solute carrier family 6 member 2

transporter

4

P33527

ABCC1

ATP binding cassette subfamily C member 1

transporter

5

P19793

RXRA

retinoid X receptor alpha

nucleic acid binding; receptor; transcription factor

6

P03372

ESR1

estrogen receptor 1

nucleic acid binding; receptor; transcription factor

7

P05412

JUN

Jun proto-oncogene, AP-1 transcription factor subunit

nucleic acid binding; transcription factor

8

P10275

AR

androgen receptor

nucleic acid binding; receptor; transcription factor

9

P37231

PPARG

peroxisome proliferator activated receptor gamma

nucleic acid binding; receptor; transcription factor

10

P27338

MAOB

monoamine oxidase B

nucleic acid binding; oxidoreductase; transferase

11

P55055

NR1H2

nuclear receptor subfamily 1 group H member 2

nucleic acid binding; receptor;transcription factor

12

O75469

NR1I2

nuclear receptor subfamily 1 group I member 2

nucleic acid binding; receptor; transcription factor

13

P06746

POLB

DNA polymerase beta

nucleic acid binding

14

O95342

ABCB11

ATP binding cassette subfamily B member 11

hydrolase; protease

15

Q2M3G0

ABCB5

ATP binding cassettesubfamily B member 5

hydrolase; protease

16

P22303

ACHE

Acetylcholinesterase

hydrolase; protease

17

P03956

MMP1

matrix metallopeptidase 1

hydrolase; protease

18

P00734

F2

coagulation factor II, thrombin

hydrolase; protease

19

P08253

MMP2

matrix metallopeptidase 2

hydrolase; protease

20

P08183

ABCB1

ATP binding cassette subfamily B member 1

hydrolase; protease

21

P08709

F7

coagulation factor VII

hydrolase; protease

22

P45983

MAPK8

mitogen-activated protein kinase 8

kinase; transferase

23

Q13315

ATM

ATM serine/threonine kinase

kinase;nucleic acid binding; transferase

24

P06493

CDK1

cyclin dependent kinase 1

kinase; transferase

25

P48736

PIK3CG

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

kinase; transferase

26

P47989

XDH

xanthine dehydrogenase

oxidoreductase

27

P04040

CAT

catalase

oxidoreductase

28

P09917

ALOX5

arachidonate 5-lipoxygenase

oxidoreductase

29

P08684

CYP3A4

cytochrome P450 family 3 subfamily A member 4

oxidoreductase

30

P16050

ALOX15

arachidonate 15-lipoxygenase

oxidoreductase

31

P23219

PTGS1

prostaglandin-endoperoxide synthase 1

oxidoreductase

32

P05177

CYP1A2

cytochrome P450 family 1 subfamily A member 2

oxidoreductase

33

P35354

PTGS2

prostaglandin-endoperoxide synthase 2

oxidoreductase

34

Q16850

CYP51A1

cytochrome P450 family 51 subfamily A member 1

oxidoreductase

35

P09601

HMOX1

heme oxygenase 1

oxidoreductase

36

P18054

ALOX12

arachidonate 12-lipoxygenase, 12S type

oxidoreductase

37

P14550

AKR1A1

aldo-keto reductase family 1 member A1

oxidoreductase

38

O60218

AKR1B10

aldo-keto reductase family 1 member B10

oxidoreductase

39

P04141

CSF2

colony stimulating factor 2

signaling molecule

40

P10415

BCL2

BCL2, apoptosis regulator

signaling molecule

41

P01375

TNF

tumor necrosis facto

signaling molecule

42

P27487

DPP4

dipeptidyl peptidase 4

enzyme modulator; hydrolase; protease

43

P05121

SERPINE1

serpin family E member 1

enzyme modulator

44

P42574

CASP3

caspase 3

enzyme modulator; hydrolase; protease

45

P07550

ADRB2

adrenoceptor beta 2

receptor

46

P25105

PTAFR

platelet activating factor receptor

receptor

47

P08238

HSP90AB1

heat shock protein 90 alpha family class B member 1

chaperone

48

P04637

TP53

tumor protein p53

transcription factor

49

P17931

LGALS3

galectin 3

cell adhesion molecule; signaling molecule

50

P05231

IL6

interleukin 6

None

51

P00918

CA2

carbonic anhydrase 2

None

52

P00915

CA1

carbonic anhydrase 1

None

53

P01130

LDLR

low density lipoprotein receptor

None

54

P11388

TOP2A

DNA topoisomerase II alpha

None

55

P35503

UGT1A3

UDP glucuronosyltransferase family 1 member A3

None

56

O60656

UGT1A9

UDP glucuronosyltransferase family 1 member A9

None

57

P04035

HMGCR

3-hydroxy-3-methylglutaryl -CoA reductase

None

58

P10636

MAPT

microtubule associated protein tau

None

59

P26358

DNMT1

DNA methyltransferase 1

None

60

P35228

NOS2

nitric oxide synthase 2

None

61

P05093

CYP17A1

Cytochrome P450 family 17 subfamily A member 1

None

62

P16581

SELE

selectin E

None

63

P04114

APOB

apolipoprotein B

None

64

P17612

PRKACA

protein kinase cAMP-activated catalytic subunit alpha

None

65

O00255

MEN1

menin 1

None

66

P08700

IL3

interleukin 3

None

67

P19320

VCAM1

vascular cell adhesion molecule 1

None

68

Q9HAW9

UGT1A8

UDP glucuronosyl transferase family 1member A8

None

69

P29474

NOS3

nitric oxide synthase 3

None

70

Q16790

CA9

carbonic anhydrase 9

None

71

P83111

LACTB

lactamase beta

None

72

P06276

BCHE

butyrylcholinesterase

None

73

P09211

GSTP1

glutathione S-transferase pi 1

None

74

P06213

INSR

insulin receptor

None

75

P14679

TYR

tyrosinase

None

76

Q12809

KCNH2

potassium voltage-gated channel subfamily H member 2

None

77

P27169

PON1

paraoxonase 1

None