Table 3 Certainty in the estimates rated according to the GRADE. Question: Shufeng Jiedu combine antibiotic and symptomatic treatment versus antibiotic combine symptomatic treatment
Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | SFJD + usual care | usual care | Relative (95% CI) | Absolute (95% CI) | ||
Treatment failure | ||||||||||||
11 | randomised trials | serious a | not serious | not serious | serious b | Undetected | 35/422 (8.3%) | 79/393 (20.1%) | RR 0.43 (0.30 to 0.62) | 115 fewer per 1,000 (from 141 fewer to 76 fewer) | ⨁⨁◯◯ LOW | CRITICAL |
Treatment failure - Treatment duration≤7 days | ||||||||||||
6 | randomised trials | serious a | not serious | not serious | serious b | Undetected | 24/192 (12.5%) | 46/193 (12.8%) | RR 0.52 (0.33 to 0.82) | 114 fewer per 1,000 (from 160 fewer to 43 fewer) | ⨁⨁◯◯ LOW | CRITICAL |
Treatment failure - Treatment duration >7days | ||||||||||||
5 | randomised trials | serious a | not serious | not serious | serious b | Undetected | 11/230 (4.8%) | 33/200 (16.5%) | RR 0.30 (0.16 to 0.58) | 115 fewer per 1,000 (from 139 fewer to 69 fewer) | ⨁⨁◯◯ LOW | CRITICAL |
Treatment failure - Mode of administration of antibiotics - iv.gtt | ||||||||||||
2 | randomised trials | serious a | not serious | not serious | serious b | Undetected | 10/80 (12.5%) | 20/80 (25.0%) | RR 0.50 (0.25 to 1.00) | 125 fewer per 1,000 (from 188 fewer to 0 fewer) | ⨁⨁◯◯ LOW | CRITICAL |
Treatment failure - Mode of administration of antibiotics - Not reported | ||||||||||||
9 | randomised trials | serious a | not serious | not serious | serious b | Undetected | 25/342 (7.3%) | 59/313 (18.8%) | RR 0.41 (0.26 to 0.62) | 111 fewer per 1,000 (from 139 fewer to 72 fewer) | ⨁⨁◯◯ LOW | CRITICAL |
Treatment failure - Complications - Not reported | ||||||||||||
11 | randomised trials | serious a | not serious | not serious | serious b | Undetected | 29/372 (7.8%) | 65/343 (19.0%) | RR 0.43 (0.29 to 0.64) | 108 fewer per 1,000 (from 135 fewer to 68 fewer) | ⨁⨁◯◯ LOW | CRITICAL |
Treatment failure - Complications - AECOPD combined pulmonary infection | ||||||||||||
1 | randomised trials | serious a | not serious | not serious | serious b | Undetected | 6/50 (12.0%) | 14/50 (28.0%) | RR 0.43 (0.18 to 1.03) | 160 fewer per 1,000 (from 230 fewer to 8 more) | ⨁⨁◯◯ LOW | CRITICAL |
Duration of hospital stay (day) | ||||||||||||
2 | randomised trials | serious a | not serious | not serious | serious c | Undetected | 39 | 40 | – | MD 4.32 lower (5.89 lower to 2.75 lower) | ⨁⨁◯◯ LOW | CRITICAL |