Fig. 4From: Negative chronotropic and inotropic effects of lubiprostone on iPS cell-derived cardiomyocytes via activation of CFTRMechanisms of lubiprostone action on iPS-CMs. Lubiprostone decreased the beating rate and contraction ratio of iPS-CMs due to the activation of CFTR and the increase in CFTR protein at the plasma membrane though prostanoid receptor signalingBack to article page