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Table 3 The incidence of MNPCEs and PCE/NCE ratio in bone marrow of male (♂) and female (♀) Swiss albinus mice after testing for 24 h and 48 h. Data are from the controls (NaCl and NEU) and an evaluation of the genotoxicity of the lyophilized hydroalcoholic extract of S. praealtum leaves

From: Antimicrobial potential, phytochemical profile, cytotoxic and genotoxic screening of Sedum praealtum A. DC. (balsam)

TreatmentMNPCEs (n)MNPCEs (%)PCE / (PCE + NCE)
 24 h A48 h A24 h A48 h A24 h A48 h A
150 mM NaCl      
A (MNPCE); A (PCE/NCE ratio)8 ± 37 ± 30.39 ± 0.090.33 ± 0.161.00 ± 0.001.00 ± 0.00
B (MNPCE); B (PCE/NCE ratio)8 ± 311 ± 10.37 ± 0.160.53 ± 0.061.00 ± 0.001.00 ± 0.00
Mean ± SD8 ± 3 A9 ± 3 A0.38 ± 0.12 A0.43 ± 0.15 A1.00 ± 0.00 A1.00 ± 0.00 A
N–Nitroso–N–ethylurea (NEU: 50 mg/kg)    
A (MNPCE); A (PCE/NCE ratio)27 ± 933 ± 31.33 ± 0.431.63 ± 0.110.54 ± 0.040.75 ± 0.12
B (MNPCE); B (PCE/NCE ratio)68 ± 3235 ± 53.33 ± 1.541.74 ± 0.270.55 ± 0.100.54 ± 0.11
Mean ± SD48 ± 31 B34 ± 4 B2.33 ± 1.50 B1.69 ± 0.20 B0.54 ± 0.07 C0.65 ± 0.16 C
Sedum praealtum A.DC. (500 mg/kg)    
A (MNPCE); A (PCE/NCE ratio)9 ± 713 ± 80.44 ± 0.340.60 ± 0.370.90 ± 0.040.92 ± 0.02
B (MNPCE); B (PCE/NCE ratio)4 ± 25 ± 10.21 ± 0.100.24 ± 0.030.91 ± 0.030.87 ± 0.03
Mean ± SD7 ± 5 A9 ± 7 A0.33 ± 0.26 A0.42 ± 0.31 A0.90 ± 0.03 B0.89 ± 0.03 B
Sedum praealtum A.DC. (1000 mg/kg)    
A (MNPCE); A (PCE/NCE ratio)6 ± 118 ± 80.31 ± 0.070.88 ± 0.380.91 ± 0.020.91 ± 0.01
B (MNPCE); B (PCE/NCE ratio)6 ± 113 ± 10.29 ± 0.070.63 ± 0.050.91 ± 0.020.91 ± 0.02
Mean ± SD6 ± 1 A15 ± 6 A0.30 ± 0.07 A0.76 ± 0.29 A0.91 ± 0.02 B0.91 ± 0.01 B
Sedum praealtum A.DC. (2000 mg/kg)    
A (MNPCE); A (PCE/NCE ratio)9 ± 49 ± 20.46 ± 0.180.44 ± 0.090.92 ± 0.010.91 ± 0.02
B (MNPCE); B (PCE/NCE ratio)5 ± 425 ± 140.22 ± 0.181.24 ± 0.660.90 ± 0.040.91 ± 0.04
Mean ± SD7 ± 4 A17 ± 13 A0.34 ± 0.21 A0.84 ± 0.61 A0.91 ± 0.03 B0.91 ± 0.03 B
  1. Means with the same letter (A, B or C) are not significantly different (p < 0.05)