Table 1 The scores of corneal lesion in each group during the whole experiment
Group | Dose | n | CLD before ISH treatment | ||||
|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | |||
Normal | – | 15 | 15 | 0 | 0 | 0 | 0 |
Model | – | 15 | 0 | 3 | 5 | 5 | 2 |
ISH-low | 50 mg/kg | 15 | 0 | 2 | 6 | 5 | 2 |
ISH-medium | 100 mg/kg | 15 | 0 | 2 | 5 | 6 | 2 |
ISH-high | 200 mg/kg | 15 | 0 | 1 | 5 | 6 | 3 |
Group | Dose | n | CLD after 3 days of ISH treatment | ||||
0 | 1 | 2 | 3 | 4 | |||
Normal | – | 15 | 15 | 0 | 0 | 0 | 0 |
Model | – | 15 | 0 | 3 | 6 | 4 | 2 |
ISH-low | 50 mg/kg | 15 | 0 | 3 | 7 | 4 | 1 |
ISH-medium | 100 mg/kg | 15 | 0 | 4 | 6 | 4 | 1 |
ISH-high | 200 mg/kg | 15 | 2 | 3 | 5 | 4 | 1 |
Group | Dose | n | CLD after 7 days of ISH treatment | ||||
0 | 1 | 2 | 3 | 4 | |||
Normal | – | 15 | 15 | 0 | 0 | 0 | 0 |
Model | – | 14 | 0 | 4 | 5 | 4 | 1 |
ISH-low | 50 mg/kg | 15 | 2 | 4 | 6 | 3 | 0 |
ISH-medium | 100 mg/kg | 15 | 3 | 5 | 4 | 3 | 0 |
ISH-high | 200 mg/kg | 15 | 6 | 4 | 4 | 1 | 0 |
Group | Dose | n | CLD after 14 days of ISH treatment | ||||
0 | 1 | 2 | 3 | 4 | |||
Normal | – | 15 | 15 | 0 | 0 | 0 | 0 |
Model | – | 12 | 1 | 4 | 4 | 3 | 0 |
ISH-low | 50 mg/kg | 14 | 5 | 5 | 4 | 0 | 0 |
ISH-medium | 100 mg/kg | 15 | 7 | 5 | 3 | 0 | 0 |
ISH-high | 200 mg/kg | 15 | 9 | 5 | 1 | 0 | 0 |