Fig. 12

The effect of the poncirin treatment on the TNF-α (a), IL-1β (b) and IL-6 in CCL4-induced liver injury model. The CCL4 administration significantly enhanced the production of the pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6. However, the poncirin treatment markedly attenuated the production of the pro-inflammatory cytokines. The silymarin treatment also markedly reduced production of the inflammatory cytokines. The data was reported as mean ± standard deviation (*) p < 0.05, (**) p < 0.01, (***) p < 0.001, and (###) shows significant difference comparison with CCL4 treated group