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Fig. 10 | BMC Complementary Medicine and Therapies

Fig. 10

From: Mechanism of Heshouwuyin inhibiting the Cyt c/Apaf-1/Caspase-9/Caspase-3 pathway in spermatogenic cell apoptosis

Fig. 10

Schematic diagram of the mechanism of Heshouwuyin. Heshouwuyin reduced mitochondrial release of Cyt c by stabilizing mitochondrial membrane potential. After intervention with Apaf-1, Apaf-1 heptamer interaction with procaspase-9 was weakened, and the formation of apoptotic bodies was reduced, procaspase-9 was cleaved to suppress the expression of Caspase-9 and Caspase-3, thereby inhibiting the apoptosis of spermatogenic cells. However, it was also shown in the results that the effect of Heshouwuyin on the inhibition of spermatogenic cell apoptosis was also regulated by other signaling pathways

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