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Table 1 Effect of PFT on cell cycle and apoptotic regulators in tumor tissues of the different groups as determined by flow cytometry

From: A novel kefir product (PFT) inhibits Ehrlich ascites carcinoma in mice via induction of apoptosis and immunomodulation*

Groups Inocul Control PFT (pre-inocul) PFT (post-inocul)
Parameter
P53 expression 17.55±0.95 63.46± 6.72* 42.05± 6.68*†
% change from inocul control - +261% +139%
P21 expression 12.03± 0.92 55.29± 1.68* 39.60± 4.71*‡
% change from inocul control - +359% +229%
P27 expression 23.11± 1.61 60.46± 1.52* 35.96± 1.37*‡
% change from inocul control - +161% +55%
Bax expression 12.15± 0.62 52.66± 3.16* 30.62± 1.34*‡
% change from inocul control - +333% +152%
Bcl2 expression 66.89±2.34 36.47±0.89* 47.15±1.68*‡
% change from inocul control - -45% -29%
Bax/Bcl2 ratio 0.17±0.008 1.43±0.075* 0.64±0.038*‡
% change from inocul control - +741% +276%
Caspase-3 expression 20.98±1.63 46.89±2.32* 39.67±0.66*†
% change from inocul control - 123.50% 89.00%
MMP 71.14±3.27 15.86±3.69* 43.06±3.65*†
% change from inocul control - -77.7% -39.5%
  1. Each value represents the mean±SE of 6 mice/group. *P ≤ 0.01 vs. inocul control group; P < 0.05 vs. pre-inocul group; P < 0.01 vs. pre-inocul group