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Table 1 Effect of PFT on cell cycle and apoptotic regulators in tumor tissues of the different groups as determined by flow cytometry

From: A novel kefir product (PFT) inhibits Ehrlich ascites carcinoma in mice via induction of apoptosis and immunomodulation*

GroupsInocul ControlPFT (pre-inocul)PFT (post-inocul)
Parameter
P53 expression17.55±0.9563.46± 6.72*42.05± 6.68*†
% change from inocul control-+261%+139%
P21 expression12.03± 0.9255.29± 1.68*39.60± 4.71*‡
% change from inocul control-+359%+229%
P27 expression23.11± 1.6160.46± 1.52*35.96± 1.37*‡
% change from inocul control-+161%+55%
Bax expression12.15± 0.6252.66± 3.16*30.62± 1.34*‡
% change from inocul control-+333%+152%
Bcl2 expression66.89±2.3436.47±0.89*47.15±1.68*‡
% change from inocul control--45%-29%
Bax/Bcl2 ratio0.17±0.0081.43±0.075*0.64±0.038*‡
% change from inocul control-+741%+276%
Caspase-3 expression20.98±1.6346.89±2.32*39.67±0.66*†
% change from inocul control-123.50%89.00%
MMP71.14±3.2715.86±3.69*43.06±3.65*†
% change from inocul control--77.7%-39.5%
  1. Each value represents the mean±SE of 6 mice/group. *P ≤ 0.01 vs. inocul control group; P < 0.05 vs. pre-inocul group; P < 0.01 vs. pre-inocul group