Table 2 Incidence rates, hazard ratios, and confidence intervals of coronary artery disease in patients with rheumatoid arthritis using and not using Chinese herbal products, stratified by sex, age, comorbidities, and drug used
Variables | Rheumatoid Arthritis | Compared with non-CHP group | ||||||
|---|---|---|---|---|---|---|---|---|
Non-CHP group (n = 4889) | CHP group (n = 4889) | Crude HR | Adjusted HR | |||||
Event | Person years | IR† | Event | Person years | IR | (95% CI) | (95% CI) | |
Total | 356 | 23,839 | 14.93 | 212 | 26,309 | 8.06 | 0.55 (0.46–0.65)*** | 0.59 (0.5–0.71)*** |
Sex | ||||||||
Women | 294 | 20,892 | 14.07 | 172 | 22,844 | 7.53 | 0.54 (0.45–0.65)*** | 0.59 (0.49–0.72)*** |
Men | 62 | 2947 | 21.04 | 40 | 3465 | 11.54 | 0.55 (0.37–0.82)** | 0.55 (0.36–0.85)** |
Age group | ||||||||
18–39 | 35 | 6580 | 5.32 | 25 | 6942 | 3.60 | 0.68 (0.41–1.13) | 0.77 (0.45–1.32) |
40–59 | 225 | 14,471 | 15.55 | 125 | 15,966 | 7.83 | 0.51 (0.41–0.63)*** | 0.57 (0.46–0.72)*** |
≥ 60 | 96 | 2789 | 34.43 | 62 | 3401 | 18.23 | 0.55 (0.4–0.76)*** | 0.6 (0.43–0.84)** |
Baseline Comorbidity | ||||||||
Diabetes mellitus | ||||||||
No | 298 | 21,861 | 13.63 | 189 | 24,227 | 7.80 | 0.58 (0.48–0.69)*** | 0.61 (0.51–0.74)*** |
Yes | 58 | 1978 | 29.32 | 23 | 2081 | 11.05 | 0.39 (0.24–0.63)*** | 0.49 (0.29–0.82)** |
Hypertension | ||||||||
No | 194 | 18,851 | 10.29 | 130 | 21,509 | 6.04 | 0.59 (0.47–0.74)*** | 0.6 (0.48–0.76)*** |
Yes | 162 | 4989 | 32.47 | 82 | 4800 | 17.08 | 0.54 (0.41–0.7)*** | 0.6 (0.45–0.78)*** |
Hyperlipidemia | ||||||||
No | 294 | 21,399 | 13.74 | 178 | 23,381 | 7.61 | 0.56 (0.46–0.67)*** | 0.6 (0.5–0.73)*** |
Yes | 62 | 2440 | 25.41 | 34 | 2928 | 11.61 | 0.47 (0.31–0.71)*** | 0.53 (0.34–0.81)** |
COPD | ||||||||
No | 269 | 20,480 | 13.13 | 154 | 21,839 | 7.05 | 0.54 (0.45–0.66)*** | 0.62 (0.51–0.77)*** |
Yes | 87 | 3359 | 25.90 | 58 | 4470 | 12.98 | 0.5 (0.36–0.7)*** | 0.51 (0.36–0.72)*** |
ESRD | ||||||||
No | 346 | 23,608 | 14.66 | 207 | 26,109 | 7.93 | 0.55 (0.46–0.65)*** | 0.59 (0.49–0.71)*** |
Yes | 10 | 231 | 43.27 | 5 | 199 | 25.10 | 0.56 (0.19–1.65) | 1.05 (0.22–4.93) |
Drug used | ||||||||
NSAID | ||||||||
No | 2 | 70 | 28.66 | 0 | 40 | 0.00 | – | – |
Yes | 354 | 23,770 | 14.89 | 212 | 26,269 | 8.07 | 0.55 (0.46–0.65)*** | 0.59 (0.5–0.71)*** |
Corticosteroid | ||||||||
No | 340 | 22,629 | 15.02 | 199 | 24,834 | 8.01 | 0.54 (0.45–0.64)*** | 0.58 (0.49–0.7)*** |
Yes | 16 | 1210 | 13.22 | 13 | 1475 | 8.82 | 0.66 (0.32–1.38) | 0.78 (0.36–1.69) |
DMARD | ||||||||
No | 41 | 1349 | 30.39 | 12 | 611 | 19.65 | 0.71 (0.37–1.34) | 0.71 (0.35–1.42) |
Yes | 315 | 22,490 | 14.01 | 200 | 25,698 | 7.78 | 0.56 (0.47–0.67)*** | 0.58 (0.48–0.7)*** |
TNF-antagonists | ||||||||
No | 339 | 19,953 | 16.99 | 189 | 19,768 | 9.56 | 0.57 (0.48–0.68)*** | 0.58 (0.49–0.7)*** |
Yes | 17 | 3886 | 4.37 | 23 | 6541 | 3.52 | 0.79 (0.42–1.48) | 0.69 (0.36–1.32) |