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Table 2 Effect of PPE on acetic acid-induced writhing test in mice

From: A mechanistic approach to HPLC analysis, antinociceptive, anti-inflammatory and postoperative analgesic activities of panch phoron in mice

Treatment

Dose

No of writhing

% of writhing

% of writhing inhibition

Control (distilled water)

10 ml/kg

39.2 ± 1.3

100.0

0.0

Na diclofenac

10 mg/kg

13.4 ± 1.3*

34.2

65.8

PPE

100 mg/kg

35.8 ± 4.2*

91.3

8.7

PPE

250 mg/kg

24.0 ± 0.7*

61.2

38.8

PPE

500 mg/kg

18.2 ± 1.7*

46.4

53.6

PPE (500 mg/kg) +

Naloxone (2 mg/kg)

 

13.5 ± 0.4*

34.4

65.6

  1. N = 6. Values are mean ± SEM. *p < 0.05 compared to control (One-Way ANOVA followed by Dunnett’s post hoc test)