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Fig. 5 | BMC Complementary Medicine and Therapies

Fig. 5

From: Role of limonin in anticancer effects of Evodia rutaecarpa on ovarian cancer cells

Fig. 5

Activation of p53-mediated apoptosis by limonin in SKOV-3 cells. (a) Immunoblotting analysis of expression levels of proteins involved in the apoptotic pathway in cells treated with limonin (1, 2, 5, and 10 μM) or DMSO (control) for 24 h. (b–h) Quantification of p53 (b), Bax (c), Bcl-2 (d), survivin (e), p21 (f), cleaved caspase-3 (g), and cleaved PARP1 (h) levels (mean ± SEM) in (a). α-Tubulin was used as a loading control. *P < 0.05, **P < 0.01, ***P < 0.001

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